Circulating and non-circulating proteins and nucleic acids as biomarkers and therapeutic molecules in ovarian cancer
作者机构：Department of Microbiology and BiotechnologyShoolini UniversitySolanHimachal Pradesh 173229India Faculty of Applied Science and BiotechnologyShoolini UniversitySolanHimachal Pradesh 173229India Tisch Cancer InstituteIcahn School of MedicineMt.SinaiNY 10029USA Department of Autoimmune DiseasesFeinstein Institute for Medical ResearchNorthwell HealthManhassetNY 11030USA Vascular Interventional RadiologyDepartment of RadiologyMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第3期
页 面：1005-1018页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Biomarker Circulating protein Exosomes Extracellular vesicles Ovarian cancer Proteonnics
摘 要：Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nanovesicle technology such as exosomes, proteomic and genomics studies could further contribute to better identification of anomalous protein and networks which could act as potential targets for biomarker and immunotherapy development. This review provides an overview of the circulating and non-circulating biomarkers with the aim of addressing the current challenges and potential biomarkers that could lead to early ovarian cancer diagnosis and better management. By means of this review we also lay a hypothesis that characterization of exosomal protein, nucleic acid content from body fluids (serum, plasma, urine, etc.) can decode the secret of disease and potentially improve diagnostic sensitivity which could further lead to more effective screening and early detection of the disease.
维普期刊数据库