Mutation N856K in spike reduces fusogenicity and infectivity of Omicron BA.1

作     者：Chunyun Sun Huiyu Wang Ji Yang Desheng Kong Yuning Chen Haiyue Wang Lingling Sun Jianbo Lu Min Teng Liangzhi Xie Chunyun Sun;Huiyu Wang;Ji Yang;Desheng Kong;Yuning Chen;Haiyue Wang;Lingling Sun;Jianbo Lu;Min Teng;Liangzhi Xie

作者机构：Beijing Engineering Research Center of Protein and AntibodySinocelltech Ltd.Beijing 100176China Beijing Key Laboratory of Monoclonal Antibody Research and DevelopmentSino Biological Inc.Beijing 100176China Cell Culture Engineering CenterChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第3期

页      面：908-911页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：Beijing Municipal Science and Technology Commission(Z211100002521026). 

主　　题：lung pathology damage 

摘      要：Dear Editor,COVID-19 lung pathology is characterized by interstitial pneumonia with cell-cell fusion-induced syncytia and extensive tissue damage.1 The correlation between viral fusogenicity and pathogenicity has been reported in SARS-CoV-2 variants.2 Compared with the previous Delta or D614G variants,Omicron BA.1 has been proven to be less fusogenic and pathogenic.