Prognostic value of the RNA editing enzyme: ADAR1, and its association with immune cells infiltration in pancreatic adenocarcinoma
作者机构：Key Laboratory of Molecular Target&Clinical Pharmacology and the State&NMPA Key Laboratory of Respiratory DiseaseSchool of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhouGuangdong 511436China Yunnan Digestive Endoscopy Clinical Medical CenterDepartment of GastroenterologyThe First People's Hospital of Yunnan ProvinceKunming 650032China Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China State Key Laboratory of Respiratory DiseaseGuangdong-Hongkong-Macao Joint Laboratory of Respiratory Infectious DiseaseGuangzhouGuangdong 510182China Sydney Vital Translational Cancer Research CentreWestbourne StNSW 2065Australia
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2023年第10卷第1期
页 面：41-44页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the Foundation for Studying Abroadfrom the ChinaScholarship Counc(ilNo.201906210477) the High-level University Construction Fund of Guangdong Province(China)(No.06-410-2106,154,06-410-2106,153,06-410-2107,229) the Yunnan Digestive Endoscopy Clinical Medical Center Foundation for Health Commission of Yunnan Province(China)(No.2021LCZXXFXH018 of 2X2019-01-02) the fund of Guangdong-Hongkong-Macao Joint Laboratory of Respiratory Infectious Disease for Dr Wenjie Chen(No.GHMJLRID-Z-202113).
主 题：ADAR1 adenocarcinoma editing
摘 要：The adenosine deaminase acting on RNA(ADAR)protein family was well characterized as RNA editing enzymes converting adenosines to inosines(A-to-l)in dsRNA structures.They share a homologous structure including the dsRNA-binding domain and the deaminase domain.ADAR1 function as the primary editing enzyme for A-to-l mutation because of its higher and ubiquitous expression compared to ADAR2 and ADAR3 in eukaryotes.
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