Impact of citrus fruit and hesperidin intake on multiple health outcomes:An umbrella review

作     者：Yu-Sen Cheng Yong Zhou Yu-Sen Cheng;Yong Zhou

作者机构：Division of Gastrointestinal SurgeryDepartment of General SurgeryWest China HospitalSichuan UniversityChengduSichuanChina 

出 版 物：《Journal of Nutritional Oncology》 (肿瘤营养学杂志（英文）)

年 卷 期：2023年第8卷第1期

页      面：16-24页

学科分类：09[农学] 0902[农学-园艺学] 090201[农学-果树学] 

基　　金：This work was supported by a Chinese Medical Board Grant on Evidence-Based Medicine,New York(No.98-680) the National Natural Science Foundation of China(No.30901427) a Sichuan Provincial Science and Technology Support Project(No.2016SZ0047) 

主　　题：Citrus fruit Hesperidin Health Umbrella review Meta-analysis Systematic review 

摘      要：Citrus fruits are rich sources of several biologically active flavonoids such as hesperidin,naringin,and polymethoxylated *** evaluated the evidence of associations between citrus fruit or hesperidin intake and multiple health *** umbrella review was conducted for studies performed in ***,246 articles were initially identified by searching in 4 ***-two meta-analyses and systematic reviews with 28 health outcomes met the inclusion *** fruit intake had beneficial effects on all-cause mortality(relative risk[RR].0.90;95%confidence interval[95%CI],0.86 to 0.94),cardiovascular diseases(RR,0.78;95%CI,0.66 to 0.92),coronary heart disease(RR,0.91;95%CI,0.86 to 0.96),stroke(RR,0.74;95%CI,0.65 to 0.84),type 2 diabetes mellitus(RR,0.85;95%CI,0.78 to 0.92),and several ***-response analyses indicated that each 100-g/d increase in citrus fruit intake could reduce the risks of all-cause mortality by 6%(RR,0.94;95%CI,0.88 to 1.00),stroke by 22%(RR,0.78;95%CI,0.69 to 0.90),and cardia gastric cancer by 40%(RR,0.60;95%CI,0.44 to 0.83).Citrus fruit intake also had beneficial effects on the lipid profile and body weight control(weighted mean difference,−1.28;95%CI,−1.82 to−0.74).Grapefruits could reduce the systolic blood pressure(weighted mean difference,−2.43,95%CI,−4.77 to−0.09).Hesperidin supplementation significantly improved *** fruit intake was generally safe and beneficial for multiple health outcomes in ***,grapefruit and pomelo juice may affect the bioavailability of various medications,so care should be exercised before increasing the intake of these fruits or their juices.