Blending with transition metals improves bioresorbable zinc as better medical implants

作     者：Yingchao Su Jiayin Fu Juncen Zhou Elias Georgas Shaokang Du Yi-Xian Qin Yadong Wang Yufeng Zheng Donghui Zhu 

作者机构：Department of Biomedical EngineeringStony Brook UniversityStony BrookNYUSA Nancy E.and Peter C.Meinig School of Biomedical EngineeringCornell UniversityIthacaNYUSA Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhouZhejiangChina Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina School of Materials Science and EngineeringPeking UniversityBeijingChina 

出 版 物：《生物活性材料(英文)》 (Bioactive Materials)

年 卷 期：2023年第20卷第2期

页      面：243-258页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：supported by the National Institutes of Health[Grant number R01HL140562 R01DK129493 to D.Zhu] 

主　　题：Degradation Cardiovascular Orthopedic Subcutaneous Antibacterial 

摘      要：Zinc(Zn)is a new class of bioresorbable metal that has potential for cardiovascular stent material,orthopedic implants,wound closure devices,***,pure Zn is not ideal for these applications due to its low mechanical strength and localized degradation *** is the most common/effective way to overcome this ***,the choice of alloying element is crucial to ensure the resulting alloy possesses sufficient mechanical strength,suitable degradation rate,and acceptable ***,we proposed to blend selective transition metals(i.e.,vanadium-V,chromium-Cr,and zirconium-Zr)to improve Zn’s *** selected transition metals have similar properties to Zn and thus are beneficial for the metallurgy process and mechanical ***,the biosafety of these elements is of less concern as they all have been used as regulatory approved medical implants or a component of an implant such as Ti6Al4V,CoCr,or Zr-based dental *** study showed the first evidence that blending with transition metals V,Cr,or Zr can improve Zn’s properties as bioresorbable medical *** addition,three in vivo implantation models were explored in rats:subcutaneous,aorta,and femoral implantations,to target the potential clinical applications of bioresorbable Zn implants.