Autophagy and microRNA in hepatitis B virus-relatedhepatocellular carcinoma

作     者：Shan-Ying Wu Sheng-Hui Lan Hsiao-Sheng Liu 

作者机构：Institute of Basic Medical SciencesCollege of MedicineNational Cheng Kung UniversityTainan 701Taiwan Department of Microbiology and ImmunologyCollege of MedicineNational Cheng Kung UniversityTainan 701Taiwan Center of Infectious Disease and Signaling ResearchCollege of MedicineNational Cheng Kung UniversityTainan 701Taiwan 

出 版 物：《世界胃肠病学杂志：英文版》 

年 卷 期：2016年第22卷第1期

页      面：176-187页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by Ministry of Science and Technology(NSC 101-2320-B-006-025-MY3) 

主　　题：Hepatitis B virus Autophagy MicroRNA Hepatocellular carcinoma Viral replication 

摘      要：Approximately 350 million people worldwide are chronically infected by hepatitis B virus(HBV).HBV causes severe liver diseases including cirrhosis and hepatocellular carcinoma(HCC).In about 25%of affected patients,HBV infection proceeds to HCC.Therefore,the mechanisms by which HBV affects the host cell to promote viral replication and its pathogenesis have been the subject of intensive research efforts.Emerging evidence indicates that both autophagy and micro RNAs(mi RNAs)are involved in HBV replication and HBV-related hepatocarcinogenesis.In this review,we summarize how HBV induces autophagy,the role of autophagy in HBV infection,and HBV-related tumorigenesis.We further discuss the emerging roles of mi RNAs in HBV infection and how HBV affects mi RNAs biogenesis.The accumulating knowledge pertaining to autophagy and mi RNAs in HBV replication and its pathogenesis may lead to the development of novel strategies against HBV infection and HBV-related HCC tumorigenesis.