Role of selenium in type 2 diabetes,insulin resistance and insulin secretion

作     者：Pilar Casanova Daniel Monleon 

作者机构：Department of PathologyUniversity of ValenciaValencia 46010Spain 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2023年第14卷第3期

页      面：147-158页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Selenium Diabetes Insulin resistance Metabolism Antioxidants 

摘      要：Selenium is a trace mineral essential for life that acts physiologically through selenoproteins.Among other actions,the endogenous antioxidant selenoprotein glutathione peroxidase and the selenium transporter in blood,selenoprotein P,seem to play an important role in type 2 diabetes mellitus and insulin resistance by weakening the insulin signaling cascade through different mechanisms.Recent findings also suggest that selenoproteins also affect insulin biosynthesis and insulin secretion.This review discussed the role of selenium in type 2 diabetes and the complex interplay between selenoproteins and insulin pathways.