Dynamic chromatin architectures provide insights into the genetics of cattle myogenesis

作     者：Jie Cheng Xiukai Cao Xiaogang Wang Jian Wang Binglin Yue Wei Sun Yongzhen Huang Xianyong Lan Gang Ren Chuzhao Lei Hong Chen Jie Cheng;Xiukai Cao;Xiaogang Wang;Jian Wang;Binglin Yue;Wei Sun;Yongzhen Huang;Xianyong Lan;Gang Ren;Chuzhao Lei;Hong Chen

作者机构：College of Animal Science and TechnologyNorthwest A&F UniversityNo.22 Xinong RoadYangling districtYanglingShaanxi province 712100China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and UtilizationSouthwest Minzu UniversityChengdu 610225China College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China College of Animal ScienceXinjiang Agricultural UniversityUrumqi 830052China 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2023年第14卷第4期

页      面：1344-1362页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 090501[农学-动物遗传育种与繁殖] 

基　　金：supported by the National Natural Science Foundation of China[Grant No.31972558] the Agricultural Improved Seed Project of Shandong Province[Grant No.2020LZGC014-03] 

主　　题：Cattle Cis-regulatory elements Muscle Selection sweep 3D genome 

摘      要：Background Sharply increased beef consumption is propelling the genetic improvement projects of beef cattle in ***-dimensional genome structure is confirmed to be an important layer of transcription *** genome-wide interaction data of several livestock species have already been produced,the genome structure states and its regulatory rules in cattle muscle are still *** Here we present the first 3D genome data in Longissimus dorsi muscle of fetal and adult cattle(Bos taurus).We showed that compartments,topologically associating domains(TADs),and loop undergo re-organization and the structure dynamics were consistent with transcriptomic divergence during muscle ***,we annotated cis-regulatory elements in cattle genome during myogenesis and demonstrated the enrichments of promoter and enhancer in selection *** further validated the regulatory function of one HMGA2 intronic enhancer near a strong sweep region on primary bovine myoblast *** Our data provide key insights of the regulatory function of high order chromatin structure and cattle myogenic biology,which will benefit the progress of genetic improvement of beef cattle.