Impact of pretransplant asplenia vaccination on anti-A/B antibody titers in prospective ABO incompatible kidney transplant recipients

作     者：Elisa Bongetti Mauro S.Sandrin William R.Mulley Elisa Bongetti;Mauro S. Sandrin;William R. Mulley

作者机构：Department of NephrologyMonash HealthClaytonVictoriaAustralia Department of SurgeryAustin Health/Northern HealthThe University of MelbourneHeidelbergVictoriaAustralia 

出 版 物：《Rheumatology & Autoimmunity》 (风湿病与自身免疫（英文）)

年 卷 期：2023年第3卷第1期

页      面：26-34页

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：ABO blood-group system asplenia kidney transplantation molecular mimicry splenectomy vaccination 

摘      要：Background:Asplenia vaccination is employed before ABO-incompatible(ABOi)transplantation in case splenectomy is *** vaccines have been reported,in different patient groups,to increase anti-A/B titers,through cross-reactivity to shared polysaccharide *** investigated the impact of pretransplant asplenia vaccinations on anti-A/B antibody titers in prospective ABOi renal transplant ***:Published asplenia vaccine microbial structures were reviewed to assess expression of A/B *** patients who underwent ABOi transplantation at Monash Medical Centre with anti-A/B titers taken either side of asplenia vaccination were included in a retrospective cohort study between 2007 and *** with paired titers without intervening vaccination were included as *** titers were compared within ***:A and B antigens were found to be expressed by vaccine specific pneumococcal ***-nine ABOi renal transplant recipients received vaccination including at least one pneumococcal *** most common donor to recipient combination was A1 to *** median pre-and postvaccination anti-A/B titers were 1:32 and there was no significant change in titers following vaccination(median change in titer 0 dilutions,range–2 to 3,P=0.43).The same findings were apparent in the control group(n=20).There was no significant change in titer by donor blood group or vaccine *** transplants were canceled or delayed by a rise in anti-A/B titers ***:Pneumococcal vaccination had no clinically relevant impact on anti-A/B titers before ABOi transplantation in this *** results provide reassurance regarding the safety of asplenia vaccination before ABOi transplantation.