Alteration of faecal microbiota balance related to long-term deep meditation
作者机构:Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic DisordersShanghaiChina Shanghai Institute of Traditional Chinese Medicine for Mental HealthShanghaiChina Department of PharmacologyShaheed Zulfiqar Ali Bhutto Medical UniversityIslamabadPakistan
出 版 物:《General Psychiatry》 (综合精神医学(英文))
年 卷 期:2023年第36卷第1期
页 面:1-8页
核心收录:
学科分类:0402[教育学-心理学(可授教育学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 1009[医学-特种医学] 10[医学]
基 金:This work was supported by the National Natural Science Foundation of China(grants 81571326(2021-TX-004),81671336,81501153) Chinese‘111 Project’(grant B08020) Shanghai Jiao Tong University art and science Grants(grant 14JCRZ05) Startup funding of Shanghai Mental Health Center(grant 2017-kyqd-01) Personnel Training Program of Shanghai Mental Health Center(grants 2018-FX-02,2021-QH-04) National Key R&D Program of China(grant 2017YFC0909200) Excellence Journal Project in China(grant C-198)
摘 要:Background Advancements in research have confirmed that gut microbiota can influence health through the microbiota–gut–brain ***,as an inner mental exercise,can positively impact the regulation of an individual’s physical and mental ***,few studies have comprehensively investigated faecal microbiota following long-term(several years)deep ***,we propose that long-term meditation may regulate gut microbiota homeostasis and,in turn,affect physical and mental *** To investigate the effects of long-term deep meditation on the gut microbiome *** To examine the intestinal flora,16S rRNA gene sequencing was performed on faecal samples of 56 Tibetan Buddhist monks and neighbouring *** on the sequencing data,linear discriminant analysis effect size(LEfSe)was employed to identify differential intestinal microbial communities between the two *** Investigation of Communities by Reconstruction of Unobserved States(PICRUSt)analysis was used to predict the function of faecal *** addition,we evaluated biochemical indices in the *** Theα-diversity indices of the meditation and control groups differed *** the genus level,Prevotella and Bacteroides were significantly enriched in the meditation *** to the LEfSe analysis,two beneficial bacterial genera(Megamonas and Faecalibacterium)were significantly enriched in the meditation *** predictive analysis further showed that several pathways—including glycan biosynthesis,metabolism and lipopolysaccharide biosynthesis—were significantly enriched in the meditation ***,plasma levels of clinical risk factors were significantly decreased in the meditation group,including total cholesterol and apolipoprotein *** Long-term traditional Tibetan Buddhist meditation may positively impact physical and mental *** confirmed that the gut microbiota composition differed between the mo