Application of nanotechnology in CAR-T-cell immunotherapy

作     者：Qiang Zeng Zhigang Liu Ting Niu Chuan He Ying Qu Zhiyong Qian Qiang Zeng;Zhigang Liu;Ting Niu;Chuan He;Ying Qu;Zhiyong Qian

作者机构：Department of Hematology and Institute of HematologyState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第3期

页      面：49-65页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.31930067,31771096,31700868,31700869,and 31525009) China Postdoctoral Science Foundation(Nos.2018M633367 and 2018T110977) Post-Doc Research Project,West China Hospital,Sichuan University(No.2020HXBH165) 1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYGD18002) 

主　　题：CAR-T immunotherapy Nanotechnology Nanobody Nanoparticle 

摘      要：It is cellular immunotherapy for the tumor that the in vitro modified immunocytes from patients or donors are reinfused into patients to kill tumor *** antigen receptor T cell(CAR-T)therapy,one of the most successful and representative tumor cellular immunotherapies,is now the weapon for cancer after extensive *** CAR-T immunotherapy achieves success in treating relapsed/refractory hematological tumors,its drawbacks,including the poor effect in solid tumors,cytokine release syndrome(CRS)or CAR-T-related encephalopathy syndrome(CRES),on-target,off-tumor effect,and high cost,cannot be *** is advantageous in the construction of CARs,the transfection of T cells,the expansion,delivery,and antitumor effect of CAR-T cells,and the reduction of CAR-T therapy-associated ***,introducing nanotechnology into CAR-T immunotherapy has already been performed in numerous studies with highly promising *** this review,we summarized the nanotechnologies used in CAR-T immunotherapy and discussed the challenges and directions of CAR-T immunotherapy combined with nanotechnologies in the future.