Synonymous somatic mutations that alter proximal out-of-frame downstream ATGs are associated with aberrant gene expression levels in cancer cells

作     者：Jinhui Kong Shuo Zhang Wenfeng Qian Ke Li Jinhui Kong;Shuo Zhang;Wenfeng Qian;Ke Li

作者机构：State Key Laboratory of Plant GenomicsInstitute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China University of Chinese Academy of SciencesBeijing 100049China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2023年第50卷第6期

页      面：447-449页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Key Research and Development Program of China(2019YFA0508700) the National Natural Science Foundation of China(32100443 and 31922014) 

主　　题：consequences neutral frame 

摘      要：Synonymous mutations are mutations that occur in the coding sequence of a gene but do not change the amino acid sequence of the encoded *** is now understood that synonymous mutations can have a variety of functional consequences by altering the expression of genetic information and are often non-neutral(Shen et al.,2022).