Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

作     者：Qingfei Zhang Gaizhen Kuang Wenzhao Li Jinglin Wang Haozhen Ren Yuanjin Zhao Qingfei Zhang;Gaizhen Kuang;Wenzhao Li;Jinglin Wang;Haozhen Ren;Yuanjin Zhao

作者机构：Department of Hepatobiliary SurgeryThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolHepatobiliary Institute of Nanjing UniversityNanjing 210008People’s Republic of China Oujiang Laboratory(Zhejiang Lab for Regenerative MedicineVision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325001People’s Republic of China State Key Laboratory of BioelectronicsSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096People’s Republic of China Chemistry and Biomedicine Innovation CenterNanjing UniversityNanjing 210023People’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2023年第15卷第3期

页      面：299-331页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 0901[农学-作物学] 0703[理学-化学] 0836[工学-生物工程] 10[医学] 

基　　金：the financial support from the National Key Research and Development Program of China(2020YFA0908200) the National Natural Science Foundation of China(52103196 and 52073060) Guangdong Basic and Applied Basic Research Foundation(2021B1515120054) the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038)。 

主　　题：Stimuli-responsive Nanocarrier Gene therapy Gene delivery Cancer 

摘      要：Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects.Currently,the development of functional vectors with safety and effectiveness is the intense focus for improving the delivery of nucleic acid drugs for gene therapy.For this purpose,stimuli-responsive nanocarriers displayed strong potential in improving the overall efficiencies of gene therapy and reducing adverse effects via effective protection,prolonged blood circulation,specific tumor accumulation,and controlled release profile of nucleic acid drugs.Besides,synergistic therapy could be achieved when combined with other therapeutic regimens.This review summarizes recent advances in various stimuliresponsive nanocarriers for gene delivery.Particularly,the nanocarriers responding to endogenous stimuli including pH,reactive oxygen species,glutathione,and enzyme,etc.,and exogenous stimuli including light,thermo,ultrasound,magnetic field,etc.,are introduced.Finally,the future challenges and prospects of stimuli-responsive gene delivery nanocarriers toward potential clinical translation are well discussed.The major objective of this review is to present the biomedical potential of stimuli-responsive gene delivery nanocarriers for cancer therapy and provide guidance for developing novel nanoplatforms that are clinically applicable.