Multidimensional Mass Spectrometry Assisted Metallo-Supramolecular Chemistry

作     者：Heng Wang Chenxing Guo Xiaopeng Li 

作者机构：College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518073 Shenzhen University General HospitalShenzhen University Clinical Medical AcademyShenzhen 518055 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2022年第4卷第3期

页      面：785-808页

学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：X.L.acknowledges the support from the Developmental Fund for Science and Technology of Shenzhen government(grant no.RCJC20200714114556036) Tencent Funders Alumni Foundation.H.W.thanks the support from the National Natural Science Foundation of China(no.22001176). 

主　　题：mass spectrometry ion mobility selfassembly metallo-supramolecules 

摘      要：Metallo-supramolecular chemistry based on the reversible,directional,and predictable noncovalent interaction of metal–ligand coordination has been widely applied in constructing a myriad of two-and threedimensional supramolecules with sophisticated structures.The development of metallo-supramolecular chemistry highly relies on facile characterization methods.For advancement of structural complexity with desired functions,however,conventional crystallographicandspectroscopiccharacterizationsarelimited by crystal growth,sample purity,and severe signal overlaps.With high sensitivity and low requirement for purity,multidimensional mass spectrometry(MS),including electrospray ionization-MS(ESI-MS),tandem MS(MS2),and ion mobility-MS(IM-MS),is emerging as an essential analytical tool for characterization of the chemical compositions,connectivity,stability,shape,and size of metallo-supramolecules,as well as kinetic and thermodynamic features of self-assembly processes.Thus,this review mainly focuses on the recentdevelopment ofmultidimensionalMSinmetallosupramolecular characterization and discusses how ESI-MS,MS2,and IM-MS assist the development of metallo-supramolecular chemistry.