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Aggregate 2024年第1期5卷 130-147页

作者： Yuwei Liu Shuting Xu Qingyang Lyu Yi Huang Weiping Wang State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Laboratory of Molecular Engineering and Nanomedicine Dr.Li Dak-Sum Research CentreThe University of Hong KongHong KongChina

Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient prognosis.Photodynamic therapy(PDT)has been widely applied as an antitumor modality,owing to its minimal invasiveness,localized tumor damage,and high safety profile.However,its efficacy is limited by poor stability of photosensitizers,inadequate tumor accumulation,and a complex tumor microenvironment.To overcome these challenges,extensive endeavors have been made to explore the co-assembly of the widely used photosensitizer chlorin e6(Ce6)with various functional small molecules to enhance pharmacodynamic activity.This review provides a comprehensive overview of current studies on Ce6-based nanoparticles for effective PDT and precise delivery of functional molecules.The self-assembly mechanism will be discussed in detail,with a focus on potential strategies for combinational therapy with PDT.

关键词： cancer treatment carrier-free chlorin e6(Ce6) light nanomedicine photodynamic therapy(PDT) selfassembly

Multidimensional Mass Spectrometry Assisted Metallo-Supramolecular Chemistry

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CCS Chemistry 2022年第3期4卷 785-808页

作者： Heng Wang Chenxing Guo Xiaopeng Li College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518073 Shenzhen University General Hospital Shenzhen University Clinical Medical AcademyShenzhen 518055

Metallo-supramolecular chemistry based on the reversible,directional,and predictable noncovalent interaction of metal–ligand coordination has been widely applied in constructing a myriad of two-and threedimensional supramolecules with sophisticated structures.The development of metallo-supramolecular chemistry highly relies on facile characterization methods.For advancement of structural complexity with desired functions,however,conventional crystallographicandspectroscopiccharacterizationsarelimited by crystal growth,sample purity,and severe signal overlaps.With high sensitivity and low requirement for purity,multidimensional mass spectrometry(MS),including electrospray ionization-MS(ESI-MS),tandem MS(MS2),and ion mobility-MS(IM-MS),is emerging as an essential analytical tool for characterization of the chemical compositions,connectivity,stability,shape,and size of metallo-supramolecules,as well as kinetic and thermodynamic features of self-assembly processes.Thus,this review mainly focuses on the recentdevelopment ofmultidimensionalMSinmetallosupramolecular characterization and discusses how ESI-MS,MS2,and IM-MS assist the development of metallo-supramolecular chemistry.

关键词： mass spectrometry ion mobility selfassembly metallo-supramolecules

Anion-Coordination-Driven Assembly of Anionic Hexagonal and Square Architectures and the Structural Interconversion

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CCS Chemistry 2022年第6期4卷 2043-2052页

作者： Cong Zhao Jie Zhao Dong Yang Tanya KRonson Le Yu Huizheng Zhang Wenyao Zhang Fen Zhao Wei Sun Xiao-Juan Yang Biao Wu Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710069 Department of Chemistry University of CambridgeCambridge CB21EW

A biphenyl-bridged bis-tris(urea)ligand L was rationally designed with a favorable angle to construct a hexagon-shaped A_(6)L_(6)(A=anion)complex upon assembly with phosphate anions(PO_(4)^(3−))via anioncoordination-driven assembly(ACDA).Due to the moderate flexibility of L,another well-defined discrete architecture,a square-like A_(4)L_(4) complex,has also been obtained from ligand L and PO_(4)^(3−).Interconversion between these two self-assemblies can be readily realized by solvent regulation.In addition,the two anionic architectures display different binding abilities for selected cationic guest molecules,enabling the uptake of a desired guest from amixture of guests.

关键词： tris(urea) anion coordination selfassembly supramolecular transformation host-guest chemistry

Various Silver Nanostructures on Sapphire Using Plasmon Self-Assembly and Dewetting of Thin Films

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Nano-Micro Letters 2017年第2期9卷 41-57页

作者： Sundar Kunwar Mao Sui Quanzhen Zhang Puran Pandey Ming-Yu Li Jihoon Lee College of Electronics and Information Kwangwoon University Institute of Nanoscale Science and Engineering University of Arkansas

Silver(Ag) nanostructures demonstrate outstanding optical, electrical, magnetic, and catalytic properties and are utilized in photonic, energy, sensors, and biomedical devices.The target application and the performance can be inherently tuned by control of configuration, shape, and size of Ag nanostructures. In this work, we demonstrate the systematical fabrication of various configurations of Ag nanostructures on sapphire(0001) by controlling the Ag deposition thickness at different annealing environments in a plasma ion coater. In particular, the evolution of Ag particles(between 2 and 20 nm),irregular nanoclusters(between 30 and 60 nm), and nanocluster networks(between 80 and 200 nm) are found be depended on the thickness of Ag thin film. The results were systematically analyzed and explained based on the solid-state dewetting,surface diffusion, Volmer–Weber growth model, coalescence,and surface energy minimization mechanism. The growth behavior of Ag nanostructures is remarkably differentiated at higher annealing temperature(750 ℃) due to the sublimation and temperature-dependent characteristic of dewetting process.In addition, Raman and reflectance spectra analyses reveal that optical properties of Ag nanostructures depend on their morphology.

关键词： Ag nanostructures Surface plasmon selfassembly Dewetting

AIE-based drug/gene delivery system:Evolution from fluorescence monitoring alone to augmented therapeutics

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Aggregate 2022年第6期3卷 60-71页

作者： Jie Sun Xuewen He The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouChina

The aggregation-induced emission luminogens(AIEgens)with unique photophysical properties propel the rapid development of novel delivery systems for drugs and genes.In this review,we first presented numeral classic types of delivery systems based on light-up AIEgens for real-time monitoring of the delivery processes and evaluation of therapeutic outcomes of delivered drugs or genes.Next,general strategies were discussed for the delicately structural design of AIEgens that can self-assemble into bright therapeutic carriers through covalent or noncovalent interactions.Furthermore,given the unprecedented enhancements in therapeutic effects through the use of multimodes of therapy,AIEgens that were endowed with multiproperties and functionalities were investigated in the constructions of delivery systems for multimodality therapy.Especially,the combinational uses of AIE photosensitizers with chemo drug and small interference RNA(siRNA)were given as examples of augmenting the therapeutic performance in drug-resistant treatment and moderate immunotherapy by showing synergistic effects.

关键词： aggregation-induced emission combinational therapy delivery systems fluorescence imaging selfassembly

Design and Synthesis of a Highly Stable Six-hydrogen-bonded Serfassembly Yellowish Green Electroluminescent Molecular Duplex

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Chinese Chemical Letters 2005年第9期16卷 1185-1188页

作者： Guang Dong LEI Yi YI Zhi Yun LU Ming Gui XIE College of Chemistry Sichuan Universtiy Chengdu 610064 Department of Chemistry and Life Science Neijiang Normal College Neijiang 641112

This paper describes the design, synthesis and characterization of a hydrogen-bonded molecular duplex with 1,8-naphthalimide fluorescent pendants. The two oligoamide molecular strands, with complementary hydrogen bond sequences of DDADAA and AADADD, can form an ultra stable self-assembly duplex. Its molecular structure was confu-med by ^1H NMR and ESI-MS, and its photoluminescence properties were determined. The resulting duplex exhibited a dramatically enhanced photoluminescence （PL） quantum efficiency of 63.7% compared to the corresponding 1,8-naphthalimide segment （32.4%）, suggesting that the formation of the duplex with larger molecular weight could successfully inhibit the quenching of the fluorescent pendant. This novel duplex is a prospective candidate for new electroluminescent emitter.

关键词： selfassembly H-bond 1 8-naphthalimide photoluminescence electroluminescence

Cluster-assembled materials:Ordered structures with advanced properties

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InfoMat 2021年第8期3卷 854-868页

作者： Qingda Liu Xun Wang Key Lab of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijingChina

Cluster-assembled materials(CAMs)present delicate structures and tailored properties,which have gained extensive interest in recent years.Due to the noncovalent linkage and size of sub-1 nm,clusters present polymer-like solution behaviors distinct from conventional nanocrystals,whereby a variety of CAMs with different constructions have been fabricated.To our knowledge,the morphologies and properties of CAMs are closely connected,which are strongly dependent on the structure and coordination state of cluster building blocks.For the CAMs with superior performances,the specific arrangement and surroundings of clusters at subnanometer scale usually result in wellorganized structures.In this review,we will summarize the recent progress of CAMs with highly ordered structures and advanced properties,where polyoxometalate cluster assemblies as well as cluster-nuclei co-assemblies are involved.The application potentials of CAMs are then discussed,especially on the cluster arrangements and interactions at subnanometer scale.However,current researches are far from reaching the point,and future efforts are needed before the nature of cluster-based nanostructures can be sufficiently revealed.We hope this article can offer unique insights and instructive understanding to the CAMs.

关键词： cluster-assembled material cluster-nuclei co-assembly polyoxometalate cluster selfassembly

Hexacyanoferrate as the Electrochemical Probe for 2-Mercaptobenzothiazole Modified Gold Electrode

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Chemical Research in Chinese Universities 1999年第2期15卷 30-35页

作者： XU Jing-juan FANG Hui-qun CHEN Hong-yuan Department of Chemistry the State Key Laboratory of Coordination ChemistryNanjing UniversityNanjing210093

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ＩｎｔｒｏｄｕｃｔｉｏｎＴｈｅｒａｔｅｏｆｅｌｅｃｔｒｏｎｔｒａｎｓｆｅｒｉｓｍｕｃｈａｆｅｃｔｅｄｂｙｓｅｖｅｒａｌｆａｃｔｏｒｓ，ｓｕｃｈａｓｅｌｅｃｔｒｏｄｅｍａｔｅｒｉａｌ，ｅｌｅｃｔｒｏｄｅｆａｂｒｉｃａｔｉｏｎｔｅｃｈｎｉｑｕｅｓ，ｐｏｌ...

关键词： Mercaptobenzothiazole selfassembly Resistance Capacitance

Synthesis of a New Porphyrin-fluorescein Hybrid and its Supramolecular Self-assembly with Amino-porphyrinatomanganese(Ⅲ) by Hydrogen-bonding

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Chinese Chemical Letters 2005年第3期16卷 303-306页

作者： JiaZhengLU JinWangHUANG LiFenFAN JieLIU KeZhuanXU XianLiCHEN LiangNianJI SchoolofChemistryandChemicalEngineering SunYat-senUniversityGuangzhou510275

A new porphyrin-fluorescein hybrid 2 (Fl-PPTPP) has been synthesized and characterized by UV-Vis, IR, 1H-NMR, ESI-MS and elemental analysis. The supramolecular self-assembly of Fl-PPTPP with amino- porphyrinatomanganese(III) [Mn(III) (p-APTPP)Cl] by hydrogen-bonding was studied using fluorescence spectroscopic titration and ESI-MS.

关键词： Porphyrin fluorescein amino-porphyrinatomanganese supramolecular selfassembly hydrogen-bonding.

2,5-Dialkoxylphenyl-l,3,4-oxadiazoles as efficient organogelators and their self-assembling property

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Frontiers of Chemical Science and Engineering 2014年第2期8卷 219-224页

作者： Zipei SUN Xuelin DONG Yan ZHAI Ziyan Li Yaodong HUANG Key Laboratory of Systems Bioengineering (Ministry of Education) School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Four 2,5-dialkoxylphenyl-l,3,4-oxadiazoles are shown to be efficient organogelators. These com- pounds readily form stable gels in many organic solvents and their gelation property as well as supramolecular structures were investigated by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, 1H nuclear magnetic resonance （1H NMR）, and ultraviolet-visible spectroscopy （UV-vis）. The results indicate that the gelator molecules self-assemble into gels with elongated fibrous networks and layer structures, and van der Waals interaction is the main driving force.

关键词： 1,3,4-oxadiazoles organogelator selfassembly