R-loop:The new genome regulatory element in plants

作     者：Jincong Zhou Weifeng Zhang Qianwen Sun Jincong Zhou;Weifeng Zhang;Qianwen Sun

作者机构：Center for Plant BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua Peking Center for Life SciencesBejing 100084China 

出 版 物：《Journal of Integrative Plant Biology》 (植物学报（英文版）)

年 卷 期：2022年第64卷第12期

页      面：2275-2289页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：the National Natural Science Foundation of China(Grant Nos.91740105 and 31822028 to Q.Sun 32100428 to J.Zhou and 32070651 to W.Zhang) supported by the Tsinghua-Peking Center for Life Sciences supported by postdoc fellowships from the Tsinghua-Peking Center for Life Sciences 

主　　题：chromatin architecture epigenetic modifications genome stability replication R-loop transcription 

摘      要：An R-loop is a three-stranded chromatin structure that consists of a displaced single strand of DNA and an RNA:DNA hybrid duplex,which was thought to be a rare by-product of ***,recent genome-wide data have shown that R-loops are widespread and pervasive in a variety of genomes,and a growing body of experimental evidence indicates that R-loops have both beneficial and harmful effects on an *** maximize benefit and avoid harm,organisms have evolved several means by which they tightly regulate R-loop ***,we summarize our current understanding of the biogenesis and effects of R-loops,the mechanisms that regulate them,and methods of R-loop profiling,reviewing recent research advances on R-loops in ***,we provide perspectives on future research directions for R-loop biology in plants,which might lead to a more comprehensive understanding of R-loop functions in plant genome regulation and contribute to future agricultural improvements.