Serum HBV RNA as a predictor of virological response in treatmentnaive chronic HBeAg-positive HBV-infected patients with normal alanine aminotransferase

作     者：Jiandan Qian Chi Zhang Huaie Liu Guiqjang Wang Hong Zhao Jiandan Qian;Chi Zhang;Huaie Liu;Guiqiang Wang;Hong Zhao

作者机构：Department of Infectious Diseases and the Center for Liver DiseasesPeking University First HospitalBeijing 100034China Department of Infectious DiseaseKunming Medical University First Affliated HospitalKunmingYunnan 650032China Department of Infectious DiseasesPeking University International HospitalBejing 102206China The Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesZhejiang UniversityHangzhouZhejang 310003China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第19期

页      面：2351-2353页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：China Mega-Project for Infectious Diseases(Nos.2013ZX10002005 and 2017ZX10203202)。 

主　　题：patients Serum treatment 

摘      要：According to current guidelines,patients with chronic hepatitis B virus(HBV)infection whose HBVDNA is positive but whose alanine aminotransferase(ALT)levels are normal do not currently need antiviral treatment, However,studies have found that even chronic HBV infection patients withnormal ALTmay,progress to cirrhosis or hepatocellular carcinoma(HCC).Furthermore,almost half of patients with normal ALT levels were found to have moderate to severe inflammation and/or significant fibrosis[2]Currently there were only a few studies on the treatment of chronic HBV patients with normal ALT levels,and the factors that affect their virological response(VR)are still unclear.An increasing number of studies have proven that serum HBV RNAcan be used as a non-invasive indicator to predict a VR,i3i In this study,weexplored the predictivevalue of HBV RNA in anticipating a VR in normal ALTchronic HBV patients.