Bone morphogenetic protein 4 induces cholinergic differentiation of brain-derived neural stem cells in vivo and in vitro

作     者：Yan Chang Jingkun Pan Lei Tian Shuilong Guo Yun Luo Xin Cui Yilong Xue 

作者机构：Laboratory of Cell Biology Institute of Geriatrics General Hospital of Chinese PLA Beijing 100853 China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2010年第5卷第21期

页      面：1611-1616页

核心收录：

学科分类：12[管理学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0710[理学-生物学] 083002[工学-环境工程] 1204[管理学-公共管理] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 0817[工学-化学工程与技术] 0837[工学-安全科学与工程] 

主　　题：bone morphogenetic protein neural stem cell induced differentiation cholinergic neuron neural regeneration 

摘      要：In vitro studies have demonstrated that many factors of bone morphogenetic proteins （BMPs） induce cholinergic differentiation of neural stem cells. However, BMP retains the potential to induce increased numbers of cholinergic neurons in central nervous system regions that are rich in cholinergic cells, which is an important determinant of BMP. Therefore, BMP-4 was added to neural stem cell culture medium or the adult rat hippocampal dentate gyrus. Results demonstrated that BMP-4 induced cholinergic differentiation of neural stem cells in vitro and increased the number of cholinergic neurons in the adult rat hippocampal dentate gyrus.