Thoracic para-aortic lymph node recurrence in patients with esophageal squamous cell carcinoma:A propensity score-matching analysis

作     者：Xu-Yuan Li Li-Sheng Huang Shu-Han Yu Dan Xie 

作者机构：Department of Medical OncologyShantou Central HospitalShantou 515041Guangdong ProvinceChina Department of Radiation OncologyCancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of RadiologyShantou Central HospitalShantou 515041Guangdong ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第36期

页      面：13313-13320页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Esophageal cancer Surgery Thoracic para-aortic lymph node Overall survival Metastasis 

摘      要：BACKGROUND Thoracic para-aortic lymph node(TPLN)recurrence in esophageal squamous cell carcinoma(ESCC)is rare and its impact on survival is *** studied survival in patients with ESCC who developed TPLN *** To study the survival in patients with ESCC who developed TPLNs *** Data were collected retrospectively for 219 patients who had undergone curative surgery for ESCC during January 2012 to November 2017 and who developed recurrences(36.29%of 604 patients who had undergone curative surgeries for ESCC).The patients were classified into positive(+)and negative(-)TPLN metastasis *** also investigated TPLN recurrence in 223 patients with ESCC following definitive chemoradiotherapy during *** propensity score matching(PSM)and survival estimation,factors predictive of overall survival(OS)were explored using a Cox proportional hazards *** Among the patients with confirmed recurrence,18 were TPLN(+)and 13 developed synchronous distant *** PSM,TPLN(+)was associated with worse recurrence-free(P=0.00049)and OS[vs TPLN(-);P=0.0027],whereas only the intergroup difference in recurrence-free survival remained significant after PSM(P=0.013).The Cox analysis yielded similar *** the patients who had received definitive chemoradiotherapy,3(1.35%)had preoperative TPLN enlargement and none had developed *** TPLN metastasis is rare but may be associated with poor survival.