Modulation of Neuronal Activity and Saccades at Theta Rhythm During Visual Search in Non-human Primates
作者机构：The Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen518055China University of Chinese Academy of SciencesBeijing100049China The Research Center for Artificial IntelligencePeng Cheng LaboratoryShenzhen518000China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2022年第38卷第10期
页 面：1183-1198页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 071006[理学-神经生物学]
基 金：We are grateful for the financial support from the National Natural Science Foundation of China(31671108 and 31800900) the National Key R&D Program of China(2017YFC1307500) the Shenzhen Science and Technology Innovation Commission(JCYJ20180508152240368) the Shenzhen Basic Research Program(JCYJ20200109114805984).
主 题：Visual search Saccade Theta rhythm FEF V4 Non-human primate
摘 要：Active exploratory behaviors have often been associated with theta oscillations in rodents,while theta oscillations during active exploration in non-human primates are still not well understood.We recorded neural activities in the frontal eye field(FEF)and V4 simultaneously when monkeys performed a free-gaze visual search task.Saccades were strongly phase-locked to theta oscillations of V4 and FEF local field potentials,and the phase-locking was dependent on saccade direction.The spiking probability of V4 and FEF units was significantly modulated by the theta phase in addition to the time-locked modulation associated with the evoked response.V4 and FEF units showed significantly stronger responses following saccades initiated at their preferred phases.Granger causality and ridge regression analysis showed modulatory effects of theta oscillations on saccade timing.Together,our study suggests phase-locking of saccades to the theta modulation of neural activity in visual and oculomotor cortical areas,in addition to the theta phase locking caused by saccade-triggered responses.
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