A multicenter, prospective, randomized clinical study to evaluate the efficacy and safety of fibrin sealant as an adjunct to sutured dural repair

作     者：Rutong Yu Wei Zhu Richard Kocharian Bogdan Ilie Zhong Wang Dezhi Kang Gang Zhao Hua Yang Kai Shu Xianzhi Liu Yiquan Ke Shun Qu Ying Mao 

作者机构：Department of NeurosurgeryThe Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu 221006China Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai 200040China EthiconInc.A Johnson&Johnson CompanyRaritanNJ 08869USA Department of NeurosurgeryThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China Department of NeurosurgeryThe First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of NeurosurgeryThe First Hospital of Jilin UniversityChangchunJilin 130499China Department of NeurosurgeryThe Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou 550004China Department of NeurosurgeryTongji HospitalTongji Medical College of HUSTWuhanHubei 430014China Department of NeurosurgeryThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of NeurosurgeryZhujiang Hospital of Southern Medical UniversityGuangzhouGuangdong 510260China EthiconJohnson&Johnson Medical(Shanghai)Co.Ltd.Shanghai 200233China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第20期

页      面：2506-2508页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：This study was funded by the Guangzhou Bioseal Biotechnology Co. Ltd 

主　　题：fibrin suture sponge 

摘      要：To the Editor:Cerebrospinal fluid(CSF)leakage increases the risk of post-operative complications following cranial surgery,and its progression is not always ***,surgeons use various methods to achieve watertight closure of CSF,including synthetic sealants,collagen or gelatin based sponges,[1]and fibrin sealants(FS).[2,3]Bioseal(Porcine Fibrin Sealant Kit,Guangzhou Bioseal Biotech Co.,Ltd.,Guangzhou,China)is a virus-inactivated porcine plasma-derived FS that has been approved as a supportive treatment to control surgical bleeding.