Helicobacter pylori infection and esophageal cancer risk:An updated meta-analysis

作     者：Fa-Jun Xie Yi-Ping Zhang Qiu-Qing Zheng Hong-Chuan Jin Fa-Liang Wang Ming Chen Lan Shao De-Hong Zou Xin-Min Yu Wei-Min Mao 

作者机构：Department of Medical Oncology Zhejiang Cancer Hospital Zhejiang Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Lung and Esophagus) Laboratory of Cancer Biology Sir Runrun Shaw Hospital Medical School of Zhejiang University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第36期

页      面：6098-6107页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by China Postdoctoral Science Foundation,No.2012M521189 Zhejiang Provincial Postdoctoral Science Foundation,No.Bsh1202064 National Natural Science Foundation ofChina,No.81172081 Zhejiang Provincial Natural Science Foundation,No.LY13H160024 Wu Jieping Medical Foundation,No.2011,3206750.11059 and 11091 

主　　题：Helicobacter pylori Esophageal carcinoma Cancer risk Meta-analysis 

摘      要：AIM:To clarify the association between Helicobacter pylori(***)infection and the risk of esophageal carcinoma through a meta-analysis of published ***:Studies which reported the association between *** infection and esophageal cancer published up to June 2013 were *** odds ratios(ORs)and corresponding 95%CIs of *** on esophageal cancer with respect to health control groups were *** were extracted independently by two investigators and discrepancies were resolved by discussion with a third *** statistical software,STATA(version 12.0),was applied to investigate heterogeneity among individual studies and to summarize the studies.A meta-analysis was performed using a fixed-effect or random-effect method,depending on the absence or presence of significant ***:No significant association between *** infection and esophageal squamous cell carcinoma(ESCC)risk was found in the pooled overall population(OR=0.97,95%CI:0.76-1.24).However,significant associations between *** infection and ESCC risk were found in Eastern subjects(OR=0.66,95%CI:0.43-0.89).Similarly,cytotoxin-associated gene-A(CagA)positive strains of infection may decrease the risk of ESCC in Eastern subjects(OR=0.77,95%CI:0.65-0.92),however,these associations were not statistically significant in Western subjects(OR=1.26,95%CI:0.97-1.63).For esophageal adenocarcinoma(EAC)the summary OR for *** infection and CagA positive strains of infection were 0.59(95%CI:0.51-0.68)and 0.56(95%CI:0.45-0.70),***:*** infection is associated with a decreased risk of ESCC in Eastern populations and a decreased risk of EAC in the overall population.