Combination therapy of hydrogel and stem cells for diabetic wound healing
作者机构：School of Biomedical EngineeringShenzhen Campus of Sun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical InstrumentSun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Endocrinology DepartmentPanyu Central HospitalGuangzhou 511400Guangdong ProvinceChina
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2022年第13卷第11期
页 面：949-961页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the Shenzhen Basic Research Project,No.JCYJ20190807155805818 the Foundation of Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument,No.2020B1212060077
主 题：Combination therapy Mesenchymal stem cells Hydrogel Diabetic wound Cells delivery Wound healing
摘 要：Diabetic wounds(DWs)are a common complication of diabetes mellitus;DWs have a low cure rate and likely recurrence,thus affecting the quality of patients’*** traditional therapy cannot effectively improve DW closure,DW has become a severe clinical medical problem *** routine wound healing,DW is difficult to heal because of its chronically arrested inflammatory *** mesenchymal stem cells and their secreted cytokines can alleviate oxidative stress and stimulate angiogenesis in wounds,thereby promoting wound healing,the biological activity of mesenchymal stem cells is compromised by direct injection,which hinders their therapeutic *** form a three-dimensional network that mimics the extracellular matrix,which can provide shelter for stem cells in the inflammatory microenvironment with reactive oxygen species in DW,and maintains the survival and viability of stem *** review summarizes the mechanisms and applications of stem cells and hydrogels in treating DW;additionally,it focuses on the different applications of therapy combining hydrogel and stem cells for DW treatment.
维普期刊数据库
