Enzymatic and chemo-enzymatic strategies to produce highly valuable chiral amines from biomass with ω-transaminases on 2D zeolites

作     者：J.Miguel Carceller Karen S.Arias Maria J.Climent Sara Iborra Avelino Corma 

作者机构：Instituto de Tecnologia Química (UPV-CSIC)Universitat Politècnica de València 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2022年第9卷第9期

页      面：10-18页

核心收录：

学科分类：0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：supported by the Spanish Government through the ‘Severo Ochoa Program’(SEV-2016–0683) the PGC2018-097 277-B-100 (MCIU/AEI/FEDER, UE) Project 

主　　题：amino transaminase ITQ-2 zeolite chemo-enzymatic process biomass semi-continuous process Pd/MgO 

摘      要：Amino transaminases(ATAs) have been supported on a 2D ITQ-2 zeolite through electrostatic interactions, resulting in a highly stable active biocatalyst to obtain a variety of valuable chiral amines starting from prochiral ketones derived from biomass. We have extended the biocatalyst applications by designing a chemo-enzymatic process that allows, as the first step, prochiral ketones to be obtained from biomass-derived compounds through an aldol condensation–reduction step using a bifunctional metal/base catalyst. The prochiral ketone is subsequently converted into the chiral amine using the immobilized ATA. We show that it is feasible to couple both steps in a semi-continuous process to produce industrially relevant chiral amines with yields of 95% and ～100% enantiomer excess.