Adhesive and Self-Healing Polyurethanes with Tunable Multifunctionality

作     者：Lei Zhou Lu Zhang Peichuang Li Manfred F.Maitz Kebing Wang Tengda Shang Sheng Dai Yudie Fu Yuancong Zhao Zhilu Yang Jin Wang Xin Li 

作者机构：School of Materials Science and EngineeringSouthwest Jiaotong UniversityDepartment of CardiologyThird People's Hospital of Chengdu Affiliated to Southwest Jiaotong UniversityChengdu610031 SichuanChina Heze BranchQilu University of Technology(Shandong Academy of Sciences)Biological Engineering Technology Innovation Center of Shandong ProvinceHeze 274000China Max Bergmann Center of Biomaterials DresdenLeibniz Institute of Polymer Research DresdenHohe Strasse 601069DresdenGermany Affiliated Dongguan HospitalSouthern Medical UniversityDongguanGuangdong 523059China Guangdong Provincial Key Laboratory of Cardiac Function and MicrocirculationGuangzhouGuangdong 510080China 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2023年第2022卷第1期

页      面：427-443页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Natural Science Foundation of China(NSFC Project 32071328 and 82072072) Sichuan Science and Technology Program(2022NSFSC0809) the International Cooperation Project by Science and Technology Department of Sichuan Province(2021YFH0056 and 2019YFH049) the High-Level Talents Research and Development Program of Affiliated Dongguan Hospital(K202102) 

主　　题：fatigue deformation catechol 

摘      要：Many polyurethanes(PUs)are blood-contacting materials due to their good mechanical properties,fatigue resistance,cytocompatibility,biosafety,and relatively good *** functionalization of the PUs using chemical synthetic methods is especially attractive for expanding their ***,a series of catechol functionalized PU(CPU-PTMEG)elastomers containing variable molecular weight of polytetramethylene ether glycol(PTMEG)soft segment are reported by stepwise polymerization and further introduction of *** the molecular weight of PTMEG fragment enables a regulable catechol content,mobility of the chain segment,hydrogen bond and microphase separation of the C-PUPTMEG elastomers,thus offering tunability of mechanical strength(such as breaking strength from 1.3 MPa to 5.7 MPa),adhesion,self-healing eficiency(from 14.9%to 96.7%within 2 hours),anticoagulant,antioxidation,anti-inflammatory properties and cellular growth *** cardiovascular stent coatings,the C-PU-PTMEGs demonstrate enough flexibility to withstand deformation during the balloon dilation *** special importance is that the C-PU-PTMEG-coated surfaces show the ability to rapidly scavenge free radicals to maintain normal growth of endothelial cells,inhibit smooth muscle cell proliferation,mediate inflammatory response,and reduce thrombus *** the universality of surface adhesion and tunable multifunctionality,these novel C-PU-PTMEG elastomers should find potential usage in artificial heart valves and surface engineering of stents.