Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats
Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats出 版 物:《癌症》 (Chinese Journal of Cancer)
年 卷 期:2003年第22卷第7期
页 面:709-709页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:肿瘤 免疫治疗 神经胶质瘤 大鼠 树突细胞 瘤体内接种
摘 要:Dendritic cells(DC)are attractive candidates for innovative cancer immunotherapy by virtu e of their ability to function as powe rful antigen presenting cells and elicit potent antitumor cytotoxic immune r *** the aim of generating antitumor immunity,the authors sought to enhance in vivo tum or antigen presentation by using an i ntratumoral DC vaccination strateg y in the setting of partially irradiated intracranial brain tumo *** rats,implanted with 9L gliomas in the right corpus striatum,w ere treated with freshly cultured,unpulsed syngeneic DC inoculated directly into the tumor *** inoculated DCs were found to drain to ipsilateral deep cervical lymph *** was a ssociated with increased local and s ystemic antitumor cytoxicity,as evidenced by robust infiltration of treated tumors with CD4and CD8T ce lls as well as by increased IFN-gamma protein and message levels in in vitr o restimulated splenic *** therapy resulted in prolonged survival and immunity to s ubsequent intracranial tumor re-ch *** results demonstrate the viability of intratumoral DC vaccination as an effectiv e therapeutic strategy for intracra nial glioma.