Intratumoral dendritic cell vaccin ation elicits potent tumoricidal im munity against malignant glioma in rats

作     者：Ehtesham M Kabos P Gutierrez MA Samoto K Black KL Yu JS 

出 版 物：《癌症》 (Chinese Journal of Cancer)

年 卷 期：2003年第22卷第7期

页      面：709-709页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：肿瘤 免疫治疗 神经胶质瘤 大鼠 树突细胞 瘤体内接种 

摘      要：Dendritic cells(DC)are attractive candidates for innovative cancer immunotherapy by virtu e of their ability to function as powe rful antigen presenting cells and elicit potent antitumor cytotoxic immune r *** the aim of generating antitumor immunity,the authors sought to enhance in vivo tum or antigen presentation by using an i ntratumoral DC vaccination strateg y in the setting of partially irradiated intracranial brain tumo *** rats,implanted with 9L gliomas in the right corpus striatum,w ere treated with freshly cultured,unpulsed syngeneic DC inoculated directly into the tumor *** inoculated DCs were found to drain to ipsilateral deep cervical lymph *** was a ssociated with increased local and s ystemic antitumor cytoxicity,as evidenced by robust infiltration of treated tumors with CD4and CD8T ce lls as well as by increased IFN-gamma protein and message levels in in vitr o restimulated splenic *** therapy resulted in prolonged survival and immunity to s ubsequent intracranial tumor re-ch *** results demonstrate the viability of intratumoral DC vaccination as an effectiv e therapeutic strategy for intracra nial glioma.