Dual autoimmune diseases:Rheumatoid arthritis with systemic lupus erythematosus and Type 1 diabetes mellitus with multiple sclerosis

作     者：Rizwan Ahmad Haseeb Ahsan Rizwan Ahmad;Haseeb Ahsan

作者机构：College of MedicineImam Abdulrahman bin Faisal UniversityDammamSaudi Arabia Department of BiochemistryFaculty of DentistryJamia Millia Islamia(A Central University)New DelhiIndia 

出 版 物：《Rheumatology & Autoimmunity》 (风湿病与自身免疫（英文）)

年 卷 期：2022年第2卷第3期

页      面：120-128页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Islamic Azad University  IAU 

主　　题：autoantibodies autoimmune diseases autoimmunity multiple sclerosis rheumatoid arthritis rhupus systemic lupus erythematosus Type 1 diabetes mellitus 

摘      要：Autoantibodies and inflammation are the hallmarks of autoimmune diseases(ADs).Organ-specific and nonorgan-specific ADs are divided according to whether the autoimmune reaction is directed against a specific tissue(e.g.,thyroid in Hashimoto s thyroiditis)or widely expressed antigens(e.g.,cell nuclei in systemic lupus erythematosus[SLE]).SLE is distinguished by the presence of circulating autoantibodies and immune complex deposition,both of which can induce inflammatory damage to many *** arthritis(RA),sometimes called inflammatory arthritis,is a systemic AD that affects the joints and causes *** sclerosis(MS)is a central nervous system inflammatory disease with various neurological and autoimmune *** have been reported between RA and SLE as well as between Type 1 diabetes mellitus and *** of shared genes and biological processes could aid in the discovery of possible treatment targets in these dual *** review article explores the molecular nature and familial inheritance of dual ADs.