Endometrial stem/progenitor cells: Properties, origins, and functions

作     者：In-Sun Hong In-Sun Hong

作者机构：Department of Health Sciences and TechnologyGAIHSTGachon UniversityIncheon 21999Republic of Korea Department of Molecular MedicineSchool of MedicineGachon UniversityIncheon 21999Republic of Korea 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第3期

页      面：931-947页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100211[医学-妇产科学] 0703[理学-化学] 10[医学] 

基　　金：supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning(No.NRF-2021R1A2C2008424 and NRF-2021M3E5E5094127) This work was supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(No.NRF-2021R1A5A2030333) This work was supported by Korea Environment Industry&Technology Institute(KEITI)through the Project(Technology Development Project for Safety Management of Household Chemical Products) funded by Korea Ministry of Environment(MOE)(No.1485017593) This research was also supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI) funded by the Ministry of Health&Welfare,Republic of Korea(No HI21C1847) 

主　　题：CD146 LGR5 0CT-4 Side population S0X9 SSEA-1 SUSD2 Wnt/β-catenin 

摘      要：The endometrium is the inner mucosal lining of the uterus that undergoes extensive cyclic growth, regeneration, differentiation, and shedding throughout the menstrual cycle in response to steroid hormones. It repeatedly undergoes approximately 450 cycles of degeneration and regeneration in a woman s lifetime. Endometrial abnormalities can be associated with repeated embryo implantation failure, recurrent spontaneous abortion, and other physiological features responsible for female infertility. This significant regenerative capacity may occur as a result of tissue-resident stem cell populations within the endometrium. Indeed, the existence of endometrial stem cells was only observed in humans and rodents through several isolation and characterization methods in the last few years. Although endometrial stem cells share various biological characteristics with other types of mesenchymal stem cells, they also show some differences in phenotype, self-renewal, and multilineage differentiation potential. Extensive studies over many years on endometrial stem cells will provide new insights into the physiology and mechanisms underlying various gynaecological diseases related to endometrial abnormalities such as female infertility, endometriosis, and endometrial cancer. Here we summarized recent studies about cellular origins and biological characteristics of endometrial stem cells. We also reviewed various recent studies to improve our understanding of their physiological roles. Many preclinical studies on their potential therapeutic applications to various endometrial diseases that could lead to reproductive dysfunction were also reviewed.