3D Printed Biomimetic Metamaterials with Graded Porosity and Tapering Topology for Improved Cell Seeding and Bone Regeneration

作     者：Lei Zhang Bingjin Wang Bo Song Yonggang Yao Seung-Kyum Choi Cao Yang Yusheng Shi 

作者机构：State Key Laboratory of Material Processing and Die&Mould TechnologySchool of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China Department of OrthopaedicsUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China George W.Woodruff School of Mechanical EngineeringGeorgia Institute of TechnologyAtlantaGA30332USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第25卷第7期

页      面：677-688页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was sponsored by the National Natural Science Foundation of China(Grant No.51922044) the Key Area Research and Development Program of Guangdong Province(No.2020B090923001) the Academic frontier youth team at Huazhong University of Science and Technology(HUST)(2018QYTD04) 

主　　题：Biomimetic biomaterials Pentamode metamaterials Selective laser melting Mass-transport properties Bone scaffolds 

摘      要：Biomimetic metallic biomaterials prepared for bone scaffolds have drawn more and more attention in recent ***,the topological design of scaffolds is critical to cater to multi-physical requirements for efficient cell seeding and bone regeneration,yet remains a big scientific challenge owing to the coupling of mechanical and mass-transport properties in conventional scaffolds that lead to poor control towards favorable modulus and permeability ***,inspired by the microstructure of natural sea urchin spines,biomimetic scaffolds constructed by pentamode metamaterials(PMs)with hierarchical structural tunability were additively manufactured via selective laser *** mechanical and mass-transport properties of scaffolds could be simultaneously tuned by the graded porosity(B/T ratio)and the tapering level(D/d ratio).Compared with traditional metallic biomaterials,our biomimetic PM scaffolds possess graded pore distribution,suitable strength,and significant improvements to cell seeding efficiency,permeability,and impact-tolerant capacity,and they also promote in vivo osteogenesis,indicating promising application for cell proliferation and bone regeneration using a structural innovation.