Altered asymmetries of resting-state MRI in the left thalamus of first-episode schizophrenia

作     者：Sha Liu Zhenglong Guo Hongbao Cao Hong Li Xiaodong Hu Long Cheng Jianying Li Ruize Liu Yong Xu Sha Liu;Zhenglong Guo;Hongbao Cao;Hong Li;Xiaodong Hu;Long Cheng;Jianying Li;Ruize Liu;Yong Xu

作者机构：Deparment of PsychiatryFirst Hospital/Fist Clinical Medical College of Shanxi Medical UniversityTaiyuanShanxiChina shanxi Key Laboratoryof Arificial Intlligence DisorderFirst Hospital of Shanxi Medical Assisted Diagnosis and Treatment for Mental UniversityTaiyuanShanxiChina School of Systems Biology.George Mason UniversityManassasVirginiaUSA Stanley Center for Psychiatric ResearchBroad Institute of MIT and HarvardCambridgeMassachusettsUSA Department of Mental HealthShanxi Medical UniversityTaiyuanShanxiChina 

出 版 物：《Chronic Diseases and Translational Medicine》 (慢性疾病与转化医学（英文版）)

年 卷 期：2022年第8卷第3期

页      面：207-217页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：National Natural Science Foundation of China(Grant/Award Number:81701326) National Key Research and Development Program of China(Grant/Award Number:2016YFC1307004) Multidisciplinary Team for Cognitive Impairment of Shanxi Science and Technology Innovation Training Team(Grant/Award Number:201705D131027) Special Project of Scientific Research Plan Talents of Shanxi Provincial Health Commission(Grant/Award Number:2020081) Shanxi Provincial Science and Technology Achievements Transformation and Guidance Project(Grant/Award Numbers:201904D131020,81971601) Shanxi Province Overseas Students Science and Technology Activity Funding Project(Grant/Award Number:20200038)。 

主　　题：asymmetry gray matter volume resting-state fMRI schizophrenia thalamus 

摘      要：Background:Schizophrenia(SCZ)is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure.Hemispheric asymmetries are a fundamental organizational principle of the human brain and relate to human psychological and behavioral characteristics.We aimed to explore the state of thalamic lateralization of SCZ.Methods:We used voxel-based morphometry(VBM)analysis,whole-brain analysis of low-frequency fluctuations(ALFF),fractional amplitude of low-frequency fluctuations(fALFF),and resting-state seed-based functional connectivity(FC)analysis to investigate brain structural and functional deficits in SCZ.Also,we applied Pearson’’s correlation analysis to validate the correlation between Positive and Negative Symptom Scale(PANSS)scores and them.Results:Compared with healthy controls,SCZ showed increased gray matter volume(GMV)of the left thalamus(t=2.214,p=0.029),which positively correlated with general psychosis(r=0.423,p=0.010).SCZ also showed increased ALFF in the putamen,the caudate nucleus,the thalamus,fALFF in the nucleus accumbens(NAc),and the caudate nucleus,and decreased fALFF in the precuneus.The left thalamus showed significantly weaker resting-state FC with the amygdala and insula in SCZ.PANSS negative symptom scores were negatively correlated with the resting-state FC between the thalamus and the insula(r=-0.414,p=0.025).Conclusions:Collectively,these results suggest the possibility of aberrant laterality in the left thalamus and its FC with other related brain regions involved in the limbic system.