Advances in traditional Chinese medicine for liver disease therapy in 2021
作者机构：Yunnan University of Traditional Chinese MedicineKunming 650500China Jiaxing Hospital of Traditional Chinese MedicineJiaxing 314033China Tianjin University of Traditional Chinese MedicineTianjin 300000China Changchun University of Traditional Chinese MedicineChangchun 130117China Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei ProvinceCangzhou 061001China
出 版 物：《Traditional Medicine Research》 (TMR传统医学研究)
年 卷 期：2022年第7卷第6期
页 面：100-117页
学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 100602[医学-中西医结合临床] 10[医学]
基 金：the First Clinical Medical School Project of Yunnan University of Traditional Chinese Medicine(No.2021Y10) the Bio-Pharmaceutical Major Science and Technology Special Project of Science and Technology Department of Yunnan Province(No.2019ZF005) the National Natural Science Foundation of China,Youth Science Foundation Project(No.82104802) the Department of Science and Technology of Yunnan Province,General Project of TCM Joint Special Project(No.202101AZ070001-064) the Jiaxing Science and Technology Bureau,Applied Basic Research(No.2022AY10003) the Cangzhou Science and Technology Bureau project(No.213106042) the Department of Science and Technology of Yunnan Province,General Project of TCM Joint Special Project(No.202001AZ070001-058)
主 题：liver disease traditional Chinese medicine extracts therapeutic mechanism intestinal barrier intestinal flora
摘 要：Liver diseases and their co-morbidities represent a major public health *** to its progressive pathogenesis and lack of effective treatment,liver disease has become one of the most important causes of death *** Chinese medicine(TCM)has potential advantages in the prevention and treatment of liver diseases,including high safety,remarkable curative effects,and low toxicity and side *** 2021,TCM extracts and their derivatives,TCM compounds,and ethnic medicines showed good efficacy in the treatment of liver *** main mechanisms and representative drugs of TCM can be summarized by the use of amygdalin,dicoumarol,quercetin,and ancient ephedrine decoction to treat hepatitis by inhibiting viral replication,as well as the use of Gentianae Radix,lupeol,Zornia diphylla(L.)Pers.,and Chinese patent medicine Liuwei Wuling tablet to alleviate acute liver injury by improving oxidative stress and inflammatory responses in the *** the treatment of alcoholic liver disease and metabolic-associated fatty liver disease,the mechanism of TCM is the inhibition of oxidative stress,improving metabolism,regulating intestinal microflora,and enhancing intestinal barrier *** representative TCM for alcoholic liver disease includes astragaloside,puerarin,patchouli alcohol,and Mori Fructus polysaccharide,while those for metabolic-associated fatty liver disease include saikosaponin,dehydroabietic acid,hesperetin,berberine,and Panax Notoginseng ***,germacrone,forsythin,geniposide,and protocatechuic acid can inhibit the activation or migration of stellate cells and improve liver ***,paeoniflorin,chrysin,and the classical prescription Huanglian decoction can significantly inhibit the proliferation of liver cancer cells and promote their apoptosis for the treatment of hepatocellular *** activation of the farnesol X receptor pathway can improve bile metabolism in the liver,thus,significantly alleviating ch
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