Facile and One-step Direct Synthesis of Poly(valine)as a Robust Drug Nanocarrier for Enhanced Breast Cancer Therapy

作     者：Ya-Bin Meng Jun Wu Ya-Bin Meng;Jun Wu

作者机构：School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China 

出 版 物：《Chinese Journal of Polymer Science》 (高分子科学（英文版）)

年 卷 期：2022年第40卷第9期

页      面：1016-1027页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 070205[理学-凝聚态物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China (No. 51973243) International Cooperation and Exchange of the National Natural Science Foundation of China (No. 51820105004) Guangdong Innovative and Entrepreneurial Research Team Program (No.2016ZT06S029) the Science and Technology Planning Project of Shenzhen (No. JCYJ20190807155801657) 

主　　题：Poly(amino acid) Nanoparticle Drug carrier Doxorubicin Breast cancer 

摘      要：Synthetic poly(amino acid)s with good biodegradable and biocompatible properties have attracted increased attention as carriers in biomedical applications in recent years,their synthesis and purification procedures are usually complicated and some by-products would occur yet.Given this,polypeptide with good biodegradable and biocompatible properties is prepared and optimized by one-step and direct synthesis strategy and poly(valine)(PVal)is selected here as a model polypeptide in this study.This newly generated PVal can self-assemble into poly(valine)nanoparticles(PVal-NPs)with a high drug-loading capacity(20 wt%)of doxorubicin(DOX)and shows strong cytotoxicity against 4T1 cells.Upon cellular internalization,the release of DOX could be accelerated by the endosomal acidic environment which leads to enhanced anticancer effects.The results in vivo show that DOX@PVal-NPs have a long blood circulation time,high cancer accumulation and penetration,and good therapeutic performance in 4T1 tumor-bearing mice without causing obvious adverse effect on main organs.With these combined advantages,these PVal-based nanoplatform would provide an effective drug delivery tool for clinical breast cancer therapy.