Intrinsic PD-L1 promotes antitumor activity of CD8^(+)cytotoxic T lymphocytes via in cis interaction with CD80
作者机构：Cheeloo College of MedicineShandong UniversityJinanShandong 250012P.R.China Key Laboratory for Experimental Teratology of Ministry of Education and Department of ImmunologySchool of Basic Medical SciencesShandong UniversityJinanShandong 250012P.R.China Shandong Key Laboratory of Gynecologic OncologyQilu Hospital of Shandong UniversityJinanShandong 250012P.R.China Key Laboratory of Infection and Immunity of Shandong ProvinceSchool of Basic Medical SciencesShandong UniversityJinanShandong 250012P.R.China Key Laboratory for Experimental Teratology of Ministry of Education and Department of Histology and EmbryologySchool of Basic Medical SciencesShandong UniversityJinanShandong 250012P.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2022年第42卷第8期
页 面：784-788页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：National Key Research and Development Program [2021YFC2300603] Taishan Scholarship [tspd20181201] Major Basic Research Project of Shandong Natural Science Foundation [ZR2020ZD12] National Natural Science Foundation of China [81830017, 31600714] China Postdoctoral Science Foundation [2016M592193, 2018M642660] National Postdoctoral Program for Innovative Talents [BX201700147] Young Scholars Program of Shandong University Young Elite Scientist Sponsorship Program by Cast [YESS20160077]
摘 要：Dear Editor,Programmed cell death-ligand 1(PD-L1)on tumor cells can inhibit CD8+cytotoxic T lymphocyte(CTL)-mediated antitumor response by trans-engagement with programmed death protein 1(PD-1).Besides tumor cells,PD-L1 is expressed on T ***,the intrinsic role of PD-L1 in T cells has not been widely ***-L1 expression is essential for the survival of activated CD8+T cells,and PD-L1 blockade at the contraction stage reduced the number of effector T cells[1].CD8+T cell responses to influenza virus infection were also impaired in PD-L1-deficient mice[2].
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