Reduced temporal activation during a verbal fluency test in clinical high risk of psychosis: a functional near-infrared spectroscopy-based study

作     者：Yanyan Wei Xiaochen Tang Tingyu Zhang Wenjun Su Lihua Xu Huiru Cui Zhenying Qian Tianhong Zhang Jijun Wang Yanyan Wei;Xiaochen Tang;Tingyu Zhang;Wenjun Su;Lihua Xu;Huiru Cui;Zhenying Qian;Tianhong Zhang;Jijun Wang

作者机构：EEG and Neuroimaging DepartmentShanghai Mental Heath Center Shanghai Jiao Tong University School of MedicineShanghaiChina The Seventh Affiliated Hospital Sun Yat-sen UniversityShenzhenChina Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT)Chinese Academy of ScienceShanghaiChina Institute of Psychology and Behavioral ScienceShanghaiJiao Tong UniversityShanghaiChina 

出 版 物：《General Psychiatry》 (综合精神医学（英文）)

年 卷 期：2022年第35卷第2期

页      面：101-108页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This research was supported by grants from the National Natural Science Foundation of China(82001406,81971251,81671329,81871050,82171497,82101582) Shanghai Science and Technology Committee Foundations(19ZR1445100,19411950800,16ZR1430500,19411969100,19410710800,21ZR1481500,20ZR1448600,21S31903100) Foundation of Shanghai Mental Health Center(2020-FX-02) Clinical Research Center at Shanghai Mental Health Center(CRC2018ZD01,CRC2018ZD04,CRC2018YB01,CRC2019ZD02) Clinical Research Center at Shanghai Jiao Tong University School of Medicine(DLY201817,20190102) Shanghai Clinical Research Center for Mental Health(19MC1911100) Project of the Key Discipline Construction,Shanghai 3-Year Public Health Action Plan(GWV-10.1-XK18) Shanghai Municipal Science and Technology Major Project(2018SHZDZX01,2018SHZDZX05)。 

主　　题：distress activation verbal 

摘      要：Background Clinical high risk(CHR)of psychosis is a state in which positive symptoms cause the subjects distress but do not approach a severity level that fulfils the criteria for a psychotic episode.CHR exhibits cognitive deficits;however,the underlying neurobiological mechanisms remain unclear.This study aimed to investigate whether brain activation measured by the levels of oxygenated hemoglobin(oxy-Hb)in CHR subjects could be correlated with cognitive deficits.Methods Fifty-eight CHR individuals who fulfilled the criteria for attenuated positive syndrome as specified in the Structured Interview for Prodromal Syndrome(SIPS)and the Scale of Prodromal Syndrome(SOPS)and 58 age-and sex-matched healthy participants were included in the study.All subjects completed the Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS)Consensus Cognitive Battery(MCCB)that includes tests measuring attention,verbal memory,verbal fluency,executive function,and general intelligence.Functional near-infrared spectroscopy(fNIRS)was used to measure the level of oxy-Hb in the dorsolateral prefrontal and frontotemporal cortices.Results We observed significantly decreased oxy-Hb levels in channel 32(located in the right superior temporal gyrus,rSTG)within the CHR individuals compared with that in the healthy controls(HCs)(t=−3.44,Bonferroni-corrected p=0.002),indicating lower brain activity.A significant positive correlation was observed between task-relatedβvalues and working memory in the CHR group(r=0.35,p=0.008).Conclusions The brain activation of rSTG is abnormal among subjects at clinicial high risk for psychosis.This abnormality is probably associated with the neural mechanisms of deficits in the working memory during the early stage of psychosis.