Computational fluid dynamics analysis and experimental hemolytic performance of three clinical centrifugal blood pumps: Revolution, Rotaflow and CentriMag
作者机构：Department of SurgeryUniversity of Maryland School of MedicineBaltimoreMDUSA Fischell Department of BioengineeringA.James Clark School of EngineeringUniversity of MarylandCollege ParkMDUSA Department of Cardiothoracic SurgeryShanghai Children's Medical CenterShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Mechanics in Energy EngineeringSchool of Mechanics and Engineering ScienceShanghai UniversityShanghaiChina.
出 版 物：《Medicine in Novel Technology and Devices》 (医学中新技术与新装备（英文）)
年 卷 期：2022年第15卷第3期
页 面：107-114页
学科分类：080704[工学-流体机械及工程] 08[工学] 0807[工学-动力工程及工程热物理]
基 金：The author(s)disclosed receipt of the following financial support for the research,authorship,and/or publication of this article:This work was funded by National Institutes of Health(Grant Numbers:R01HL118372,R01HL124170,R01HL131750,and R01HL141817) This publication was made possible by the University of Maryland Baltimore Institute for Clinical and Translational Research(ICTR)which is funded in part by Grant Number TL1 TR003100 from the National Center for Advancing Translational Sciences(NCATS)a component of the National Institutes of Health(NIH),and NIH Roadmap for Medical Research.Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the University of Maryland Baltimore ICTR,NCATS or NIH
主 题：CFD ECMO support Centrifugal blood pumps Hemolysis
摘 要：Centrifugal blood pumps have become popular for adult extracorporeal membrane oxygenation(ECMO)due to their superior blood handling and reduced thrombosis risk featured by their secondary flow paths that avoid stagnant ***,the high rotational speed within a centrifugal blood pump can introduce high shear stress,causing a significant shear-induced hemolysis *** Revolution pump,the Rotaflow pump,and the CentriMag pump are three of the leading centrifugal blood pumps on the *** many experimental and computational studies have focused on evaluating the hydraulic and hemolytic performances of the Rotaflow and CentriMag pumps,there are few on the Revolution ***,a thorough direct comparison of these three pumps flow characteristics and hemolysis is not *** this study,we conducted a computational and experimental analysis to compare the hemolytic performances of the Revolution,Rotaflow,and CentriMag pumps operating under a clinically relevant condition,i.e.,the blood flow rate of 5 L/min and pump pressure head of 350 mmHg,for adult ECMO *** silico simulations were used to characterize the shear stress distributions and predict the hemolysis index,while in vitro blood loop studies experimentally determined hemolysis *** simulation results and experimental data demonstrated that the CentriMag pump caused the lowest hemolysis while the Revolution pump generated the highest hemolysis.
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