Berberine treats atherosclerosis via a vitamine-like effect downregulating Choline-TMA-TMAO production pathway in gut microbiota
作者机构：State Key Laboratory of Bioactive Substance and Function of Natural MedicinesInstitute of Materia MedicaChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina The First Hospital of Jilin UniversityChangchunChina
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2022年第7卷第8期
页 面：3008-3020页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
基 金：funded by the CAMS Innovation Fund for Medical Sciences(CIFMS)(Nos.2021-1-I2M-007,2016-I2M-3-011) the National Natural Science Foundation of China(Nos.82173888,81973290) Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study(Z141102004414062)
摘 要：Trimethylamine-N-oxide(TMAO)derived from the gut microbiota is an atherogenic *** study investigates whether or not berberine(BBR)could reduce TMAO production in the gut microbiota and treat *** of BBR on TMAO production in the gut microbiota,as well as on plaque development in atherosclerosis were investigated in the culture of animal intestinal bacterial,HFD-fed animals and atherosclerotic patients,*** found that oral BBR in animals lowers TMAO biosynthesis in intestine through interacting with the enzyme/co-enzyme of choline-trimethylamine lyase(CutC)and flavincontaining monooxygenase(FMO)in the gut *** action was performed by BBR’s metabolite dihydroberberine(a reductive BBR by nitroreductase in the gut microbiota),via a vitamine-like effect down-regulating Choline-TMA-TMAO production *** BBR decreased TMAO production in animal intestine,lowered blood TMAO and interrupted plaque formation in blood vessels in the HFD-fed ***,21 patients with atherosclerosis exhibited the average decrease of plaque score by 3.2%after oral BBR(0.5 g,bid)for 4 months(^(*)P0.05,n=21);whereas the plaque score in patients treated with rosuvastatin plus aspirin,or clopidogrel sulfate or ticagrelor(4 months,n=12)increased by 1.9%.TMA and TMAO in patients decreased by 38 and 29%in faeces(^(*)P0.05;^(*)P0.05),and 37 and 35%in plasma(^(***)P0.001;^(*)P0.05),after 4 months on *** might treat atherosclerotic plaque at least partially through decreasing TMAO in a mode of action similar to that of vitamins.
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