Vibrio parahaemolyticus O10:K4:An Emergent Serotype with Pandemic Virulence Traits as Predominant Clone Detected by Whole-Genome Sequence Analysis--Beijing Municipality,China,2021
作者机构：Beijing Center for Disease Prevention and ControlBeijing Key Laboratory of Diagnostic and Traceability Technologies for Food PoisoningBeijingChina
出 版 物：《China CDC weekly》 (中国疾病预防控制中心周报（英文）)
年 卷 期：2022年第4卷第22期
页 面：471-477页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
摘 要：Introduction:Vibrio parahaemolyticus(***)is a common foodborne pathogen which causes gastroenteritis in humans,especially the O3:K6 pandemic clone which is still a prominent serotype in Beijing,*** this study,we observed a novel serotype O10:K4 isolated from clinical diarrhea cases,which became the most prevalent clone in ***:73 clinical isolates were collected through sentinel hospitals’surveillance in *** agglutination testing and antimicrobial susceptibility testing were *** genome sequencing was applied to characterize 73 *** strains and complete phylogenetic ***:Seven serotypes were identified among 73 strains.O10:K4 was the most common serotype(83.6%),followed by O2:KUT,O4:KUT,and O1:*** sequence typing divided the 73 isolates into 10 sequence types(STs)with ST3 as the most prevalent,which covered all O10:K4 *** isolates were sensitive to common antimicrobial agents apart from *** the O10:K4 isolates were positive for the thermostable direct hemolysin gene,toxRS/new,and orf8,and negative for the TDH-related hemolysin *** whole genome sequencing-single nucleotide polymorphism phylogenetic analysis revealed O10:K4 strains formed a main genetic lineage,which was genetically distinct from other *** also demonstrated the presence of two type III secretion system genes(T3SS1 and T3SS2)andβlactamase resistance gene blaCARB-22 in all O10:K4 ***:The study confirmed the emergence of *** O10:K4 possessing virulence factors similar to the O3:K6 pandemic clone,which may have enabled them to become prevalent in Beijing,China.
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