Assessment of phytotoxic, genotoxic and enzyme inhibition potential of Sterculia diversifolia

作     者：Fazle Rabbi Amir Zada Amna Nisar Fazle Rabbi;Amir Zada;Amna Nisar

作者机构：Department of PharmacyUniversity of PeshawarPeshawar 25120Khyber PakhtunkhwaPakistan Department of PharmacyAbasyn University PeshawarPeshawar25000Khyber PakhtunkhwaPakistan.fazle.rabbi@abasyn.edu.pk Telephone:+92-0314-9244566 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2022年第42卷第4期

页      面：595-603页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Sterculia plant extracts phytotoxic mutagenicity tests enzymes 

摘      要：OBJECTIVE:To evaluate Sterculia diversifolia stem bark and leaves for phytotoxic,genotoxic and enzymes inhibition ***:Phytotoxic activity of both stem bark and leaves were screened using Lemna *** genotoxic activity of Sterculia diversifolia stem bark and leaves extracts were tested using comet assay protocol while enzyme inhibition activity of crude extract and various fractions of both stem bark and leaves were evaluated using acetyl cholinesterase,lipoxygenase,β-glucuronidase,urease,xanthine oxidase and carbonic ***:Phytotoxic activity showed significant results in dose dependant manner in both stem bark(ethyl acetate and n-butanol)and leaves(ethyl acetate,nbutanol and n-hexane)*** genotoxic activity,dichloromethane fraction showed significant activity followed by ethyl acetate *** cholinesterease inhibitory activity showed significant results in both stem bark and leaves fractions,while significant lipoxygenase inhibition was shown by ethyl acetate,dichloromethane,crude extract and n-hexane fractions of both stem bark and leaves.β-glucuronidase,urease and carbonic anhydrase inhibitory activity showed highly significant results in ethyl acetate fraction of both stem bark and leaves,while xanthine oxidase inhibition was shown by dichloromethane fraction of stem bark and leaves ***:This study emphasizes the important phytotoxic,genotoxic and enzyme inhibition effects of Sterculia diversifolia stem bark and ***,it is clear that Sterculia diversifolia stem bark and leaves possess phytotoxic,genotoxic and enzyme inhibitory agents.