Preparation of green cellulose diacetate-based antibacterial wound dressings for wound healing

作     者：Chuang XIAO Ge ZHANG Wencheng LIANG Zhaochuang WANG Qiaohui LU Weibin SHI Yan ZHOU Yong GUAN Meidong LANG Chuang XIAO;Ge ZHANG;Wencheng LIANG;Zhaochuang WANG;Qiaohui LU;Weibin SHI;Yan ZHOU;Yong GUAN;Meidong LANG

作者机构：Key Laboratory of Advanced Polymeric MaterialsKey Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and Technology130 Meilong RoadShanghai 200237China State Key Laboratory of Bioreactor EngineeringSchool of BiotechnologyEast China University of Science and Technology130 Meilong RoadShanghai 200237China Department of General SurgeryXinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China 

出 版 物：《Frontiers of Materials Science》 (材料学前沿（英文版）)

年 卷 期：2022年第16卷第2期

页      面：83-97页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Key Research and Development Program(2016YFC1100703) 

主　　题：cellulose diacetate electrospinning antibacterial performance hemostasis wound dressing 

摘      要：Managing wounds is a growing universal problem and developing effective wound dressings to staunch bleeding and protect wounds from bacterial infections is an increasingly serious *** this work,a remolding electrospinning nanofiber three-dimensional structure wound dressing(CCP)was prepared with superhydrophilicity,high water absorption and absorbing capacity,excellent hemostatic capacity and antibacterial ability,and biocompatibility to promote wound *** guanidine hydrochloride(PHMG)was grafted to cellulose diacetate(CDA)wound dressing surface through an amide reaction.A water contact angle analysis demonstrated that CCP wound dressing could be beneficial to promote wound exudate management effectively with rapid absorption of water within 0.2 *** vitro hemo-and cytocompatibility assay showed that a CCP wound dressing had no significant hemotoxicity or ***,CCP wound dressings could be beneficial to accelerate wound hemostasis and further reduce mortality caused by uncontrolled ***,CCP wound dressings have an excellent antibacterial ability,which could be beneficial to inhibit wound inflammatory over-reaction and promote normal wound *** together,the prepared wound dressing in this research effort is expected to have high-potential in clinical applications.