Distinct structural characteristics define a new subfamily of Mycoplasma ferritin

作     者：Wenming Wang Xiaojia Liu Yajie Wang Yuan Wang Dan Fu Hongfang Xi Yi Zhao Hongfei Wang Wenming Wang;Xiaojia Liu;Yajie Wang;Yuan Wang;Dan Fu;Hongfang Xi;Yi Zhao;Hongfei Wang

作者机构：Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China State Key Laboratory of Medicinal Chemical Biology and College of PharmacyNankai UniversityTianjin 300350China Shanxi Key Laboratory of Pharmaceutical BiotechnologyTaiyuan 030006China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第11期

页      面：4952-4955页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported partially by the National Natural Science Foundation of China(Nos.62075118,21601112) the Natural Science Foundation of Shanxi Province(No.20210302123433) Key R&D program of Shanxi Province(International Cooperation,No.201903D421070,2021XM21) Shanxi Key Laboratory of Pharmaceutical Biotechnology(No.KF202003) Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2019L0020) 

主　　题：Ferritin Ferritin subfamily Ureaplasma Mycoplasma Crystal structure 

摘      要：Ferritins can generally be divided into four subfamilies based on their structural characteristics,namely,the classic ferritins(Ftns),bacterioferritins(Bfrs),DNA-binding proteins from starved cells(Dps’),and encapsulated ferritins(Enc Ftns).However,the ferritin from Mycoplasma penetrans(Mpef)possesses a particular ferroxidase center with an extreme low activity and exhibits unusual characteristics,indicating that it could be a member of a quite different subfamily of ***,the crystal structure of the ferritin from Ureaplasma urealyticum(Uurf)is presented,Mpef and Uurf have very similar properties,though they display very low sequence ***,ferritins from Mycoplasma with these unique properties do not belong to any known subfamily,but they should rather be placed in a novel ferritin subfamily,which we term Mycoplasma Ferritin(Mfr).