Distinct structural characteristics define a new subfamily of Mycoplasma ferritin
Distinct structural characteristics define a new subfamily of Mycoplasma ferritin作者机构:Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China State Key Laboratory of Medicinal Chemical Biology and College of PharmacyNankai UniversityTianjin 300350China Shanxi Key Laboratory of Pharmaceutical BiotechnologyTaiyuan 030006China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2022年第33卷第11期
页 面:4952-4955页
核心收录:
学科分类:1001[医学-基础医学(可授医学、理学学位)] 0703[理学-化学] 10[医学]
基 金:supported partially by the National Natural Science Foundation of China(Nos.62075118,21601112) the Natural Science Foundation of Shanxi Province(No.20210302123433) Key R&D program of Shanxi Province(International Cooperation,No.201903D421070,2021XM21) Shanxi Key Laboratory of Pharmaceutical Biotechnology(No.KF202003) Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No.2019L0020)
主 题:Ferritin Ferritin subfamily Ureaplasma Mycoplasma Crystal structure
摘 要:Ferritins can generally be divided into four subfamilies based on their structural characteristics,namely,the classic ferritins(Ftns),bacterioferritins(Bfrs),DNA-binding proteins from starved cells(Dps’),and encapsulated ferritins(Enc Ftns).However,the ferritin from Mycoplasma penetrans(Mpef)possesses a particular ferroxidase center with an extreme low activity and exhibits unusual characteristics,indicating that it could be a member of a quite different subfamily of ***,the crystal structure of the ferritin from Ureaplasma urealyticum(Uurf)is presented,Mpef and Uurf have very similar properties,though they display very low sequence ***,ferritins from Mycoplasma with these unique properties do not belong to any known subfamily,but they should rather be placed in a novel ferritin subfamily,which we term Mycoplasma Ferritin(Mfr).