Protein Profiles Correlated with Recurrence of Early Stage Non-Small Cell Lung Cancer

作     者：Zhe-ming Lu Shao-lin Hong 

作者机构：Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Etiology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China Duke Comprehensive Cancer Center Duke University Medical Center Durham NC 27710 USA 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2010年第22卷第1期

页      面：21-26页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by NIH grant (1RO1-CA-109384-01A) 

主　　题：Non-small cell lung cancer Recurrence Biomarker 

摘      要：Objective： To elucidate protein markers that differentiate stage I non-small cell lung cancer （NSCLC） that subsequently develop metastatic disease to those that do not develop metastasis by protein expression profiles. Methods： Matrix assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI-TOF MS） and two dimensional difference gel electrophoresis （2D-DIGE） platforms were used to separate proteins in whole tumor specimens. Quantitating mRNA expression was used for validation. Results： Twelve proteins were identified as expressed differentially between two groups from protein expression platforms. But from gene expression platform no marker could distinguish patients with recurrent vs. nonrecurrent disease. Conclusion： Analysis of multiple protein markers may be more informative to predict prognosis of early stage lung cancer.