Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N^(6)-Methyladenosine-Modified Yap Expression
作者机构：Cardiac Regeneration and Ageing LabInstitute of Geriatrics(Shanghai University)Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)School of MedicineShanghai UniversityNantong 226011China Shanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Department of CardiologyTongji HospitalTongji University School of MedicineShanghai 200065China Department of CardiologyYangpu HospitalTongji University School of MedicineShanghai 200065China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA
出 版 物：《Research》 (研究（英文）)
年 卷 期：2022年第2022卷第3期
页 面：253-269页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：the National Key Research and Development Project(2018YFE0113500 to J.J.X.) National Natural Science Foundation of China(82020108002 and 81911540486 to J.J.X.,81800358 to L.J.W.,and 82070411 to J.H.X.) Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-09-E00042 to J.J.X.) Science and Technology Commission of Shanghai Municipality(20DZ2255400 and 21XD1421300 to J.J.X.) “Dawn”Program of Shanghai Municipal Education Com mission(19SG34 to J.J.X.) Natural Science Foundation of Shanghai(19ZR1474100 to L.J.W.and 19ZR1450400 to H.B.W.)
主 题：expression. remodeling acute
摘 要：Circular RNAs take crucial roles in several pathophysiological *** regulatory role and its underlying mechanisms of circ-ZNF609 in the heart remains largely ***,we report that circ-ZNF609 is upregulated during myocardial ischemia/reperfusion(I/R)*** of circ-ZNF609 protects against acute I/R injury and attenuates left ventricle dysfunction after I/R remodeling in *** vitro,circ-ZNF609 regulates cardiomyocyte survival and proliferation via modulating the crosstalk between Hippo-YAP and Akt ***,N6-methyladenosine-modification is involved in the regulatory role of circ-ZNF609 on *** in-depth study indicates that knockdown of circ-ZNF609 decreases the expression of YTHDF3 and further fine-tuned the accessibility of Yap mRNA to YTHDF1 and YTHDF2 to regulate YAP ***-ZNF609 knockdown represents a promising therapeutic strategy to combat the pathological process of myocardial I/R injury.
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