The Study of Nerve Conduit with Biocompatibility and Electrical Stimulation Effect

作     者：郭兴蕾 刘刚 HE Qundi 徐海星 YU Yunxuan KE Changsheng MING Xiaofei ZHAO Meng WANG Xiaobin HUANG Zhijun 许沛虎 

作者机构：Department of Pharmaceutical EngineeringSchool of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China Department of PharmacyRenmin Hospital of Wuhan UniversityWuhan 430060China Wuhan Mafangshan Middle SchoolWuhan 430070China Wuhan Kanghua Century Pharmaceutical CompanyWuhan 430070China 

出 版 物：《Journal of Wuhan University of Technology(Materials Science)》 (武汉理工大学学报（材料科学英文版）)

年 卷 期：2018年第33卷第6期

页      面：1530-1539页

核心收录：

学科分类：08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：Funded by the National Natural Science Foundation of China(Nos.51473130 and 51572206) the Wuhan Huanghe Excellence Plan and Entrepreneurship Training Program of Wuhan University of Technology(Nos.20181049715010 and 20181049715018) 

主　　题：nerve injury polymer poly-dl-lactic-acid tetra-aniline conduit 

摘      要：Conductive polymers show great promise because of their electrical property based on bioelectricity in vivo. In order to search electro-activity materials which insure abduction of tissue, we synthesized conductive nerve conduits with poly-dl-lactic-acid(PDLLA) and tetra-aniline(TA). Preparation technology of TA was optimized, and the properties of the conduit were studied. RSC96 cell were used to investigate the toxicity and electrical stimulation effect. SD rats were used to assess biocompatibility in vivo. The results showed that the reaction ratio of 1:1, the reaction time of 2 h and the HCl concentration of 2 mol/L were the optimum conditions for synthesis of TA. The influence of TA content on the mechanical properties, hydrophilicity, conductivity and microstructure of the nerve conduit was evaluated. Cell and histocompatibility study showed PDLLA/TA possessed good biocompatibility. These results showed it had application values in tissue projects.