Disturbed Yin-Yang balance:stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1

作     者：Chang Yan Zhuo Luo Wen Li Xue Li Robert Dallmann Hiroshi Kurihara Yi-Fang Li Rong-Rong He Chang Yan;Zhuo Luo;Wen Li;Xue Li;Robert Dallmann;Hiroshi Kurihara;Yi-Fang Li;Rong-Rong He

作者机构：Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility Jinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE)School of PharmacyJinan UniversityGuangzhou 510632China Institute of Atmospheric Environmental Safety and Pollution ControlJinan UniversityGuangzhou 510632China Warwick Medical SchoolUniversity of WarwickCoventry CV47ALUK 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2020年第10卷第3期

页      面：383-398页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported,in part,by the National Key Research and Development Program of China,China(grant number2017YFC1700404) Natural Science Foundation of China,China(grant numbers 81622050,81573675,81673709,81560661 and81873209) the Young Top-notch Talent Support Program of Guangdong Province,China(grant numbers 2014TQ01R229 and2016TQ03R586) Guangdong Province Ocean and Fisheries Bureau-Key Technology Research and Development Program,China(grant number A201701A02) Guangdong Science and Technology Foundation for Distinguished Young Scholars,China(grant number 2017A030306004) the Science and Technology Program of Guangzhou,China(grant numbers 201604046016 and201610010182). 

主　　题：Herpes simplex virus type 1 HSV-1 Susceptibility Latency Reactivation Stress 

摘      要：Herpes simplex virus type 1(HSV-1),a neurotropic herpes virus,is able to establish a lifelong latent infection in the human host.Following primary replication in mucosal epithelial cells,the virus can enter sensory neurons innervating peripheral tissues via nerve termini.The viral genome is then transported to the nucleus where it can be maintained without producing infectious progeny,and thus latency is established in the cell.Yin-Yang balance is an essential concept in traditional Chinese medicine(TCM)theory.Yin represents stable and inhibitory factors,and Yang represents the active and aggressive factors.When the organism is exposed to stress,especially psychological stress caused by emotional stimulation,the Yin-Yang balance is disturbed and the virus can re-engage in productive replication,resulting in recurrent diseases.Therefore,a better understanding of the stress-induced susceptibility to HSV-1 primary infection and reactivation is needed and will provide helpful insights into the effective control and treatment of HSV-1.Here we reviewed the recent advances in the studies of HSV-1 susceptibility,latency and reactivation.We included mechanisms involved in primary infection and the regulation of latency and described how stress-induced changes increase the susceptibility to primary and recurrent infections.