Non-Canonical Functions of the E2F/DP Pathway with Emphasis in Plants
作者机构：Facultad de QuímicaDepartamento de BioquímicaUniversidad Nacional Autónoma de MéxicoAvenida Universidad y CopilcoCiudad de México04510México Plant Development and(Epi)Genetics GroupSwammerdam Institute for Life SciencesUniversiteit van AmsterdamAmsterdam1098XHNetherlands
出 版 物：《Phyton-International Journal of Experimental Botany》 (国际实验植物学杂志（英文）)
年 卷 期：2021年第90卷第2期
页 面：307-330页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 0901[农学-作物学] 0703[理学-化学] 0902[农学-园艺学] 10[医学]
基 金：This work was supported by Consejo Nacional de Ciencia y Tecnología[Grant No.CB220661,Postgraduate Mobility grants to V.A.S.C.and SNI III grant to S.R.R.]and Universidad Nacional Autónoma de México[DGAPA-PAPIIT IN215316,PAIP 5000-9124,PAIP 5000-9130 and PAEP-UNAM grant to V.A.S.C.].
主 题：E2F DP transcription factors atypical functions plant cells
摘 要：The E2F/DP pathway is a widely conserved regulatory mechanism in pluricellular organisms.The family of E2F and DP transcription factors was originally described having a role in the transition from the G1 to the S phase of the cell cycle.However,the discovery of hundreds of possible gene targets and their involvement in many other biochemical processes,soon showed that they participated in cell development and differentiation,chromatin remodeling,DNA repair and others.The E2F/DP transcription factors can act as either activators or repressors of transcription depending on their association to other regulatory proteins,particularly the retinoblastoma protein,or even depending to their protein structure that can define their role.In plants the E2F/DP pathway also regulates endoreduplication,a process present along the life cycle,from organ elongation to root differentiation and reproduction.These transcription factors also help plant cells to respond to environmental disturbances such as those caused by different types of radiation,or by pathogens.This review focuses on the“so callednon-canonical functions of the E2F/DP family proteins in animal and plant cells,that are in fact essential activities that connect regulatory circuits among multiple metabolic pathways by means of their atypical functions.
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