Are BCL6 and EZH2 novel therapeutic targets for systemic lupus erythematosus?

作     者：Shu Ding Yu Rao Qianjin Lu 

作者机构：Department of DermatologyThe Third Xiangya Hospital of Central South University#138 Tongzipo RoadChangsha 410013 HunanChina Institute of DermatologyChinese Academy of Medical Sciences and Peking Union Medical College#12 Jiangwangmiao StreetXuanwuNanjing 210042 JiangsuChina Key Laboratory of Basic and Translational Research on Immune-Mediated Skin DiseasesChinese Academy of Medical SciencesNanjing 210042China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2022年第19卷第7期

页      面：863-865页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：This work was supported by grants from the National Natural Science Foundation of China(Nos.81830097,81972921) the Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences(2021-RC320-001,2020-RC320-003) the Hunan Provincial Natural Science Foundation of China(No.2020JJ5849) the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(No.YX202101) Fundamental Research Funds for the Central Universities of Central South University(No.1053320216463). 

主　　题：EZH2 erythematosus lupus organs 

摘      要：As a chronic systemic autoimmune disease,systemic lupus erythematosus(SLE)can influence multiple organs and systems.Although the pathological basis and risk factors for SLE have been extensively investigated,the exact pathogenesis of SLE remains to be explored.However,there is increasing evidence that T-cell−Bcell interactions promote the development of SLE,resulting in the generation of high-affinity antibodies[1].Tfh cells,a subgroup of T cells,can promote the formation of germinal centers,the maturation of B cells,and the differentiation of plasma cells[2].It has been found that multiple transcription factors(TFs)can regulate the generation of Tfh cells.For instance,B-cell lymphoma-6(BCL-6),an evolutionarily conserved zinc-finger protein,is an important positive transcription factor responsible for the differentiation and maturation of Tfh cells.In addition to maintaining the phenotype and GC response of Tfh cells,BCL-6 can also regulate the dynamics of T-cell−B-cell interactions and improve the efficiency of delivering help to B cells[3].