Outcome of patients with primary sclerosing cholangitis and ulcerative colitis undergoing colectomy
Outcome of patients with primary sclerosing cholangitis and ulcerative colitis undergoing colectomy作者机构：Division of GastroenterologyDepartment of MedicineFaculty of MedicineChulalongkorn UniversityBangkok 10330Thailand Department of Internal MedicineSection of Gastroenterology and HepatologyThe National University Hospital of IcelandIS121 ReykjavikIceland Division of Gastroenterology and HepatologyMayo ClinicRochesterMN 55905United States Health SolutionsArizona State UniversityAZ 85004United States
出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)
年 卷 期：2013年第4卷第3期
页 面：61-68页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by A Medical Research Scholarship from the Faculty of Medicine,Chulalongkorn University and King Chulalongkorn Memorial Hospital(Thai Red Cross Society,Bangkok,Thailand) to Treeprasertsuk S A One-Year Research Scholarship from the Hellenic Association for the Study of the Liver to Sinakos E
主 题：Prognosis Colectomy Primary sclerosing cholangitis Ulcerative colitis Outcomes
摘 要：AIM:To study the outcomes of primary sclerosing cholangitis(PSC) patients with ulcerative colitis(UC) undergoing ***:We identified 193 patients with PSC and UC undergoing colectomy at the Mayo Clinic(Rochester,MN,United States),between January 1,1995 and December 31,2008 using a computerized record ***-nine patients were excluded due to unclear diagnosis,liver transplantation prior to colectomy,age less than 18 years,inadequate follow-up data or known cases of *** retrospectively reviewed data from patient medical *** information,date of colectomy,preoperative and follow-up liver tests and pathological findings of the colon were *** Mayo risk score at baseline was calculated to obtain survival estimates for up to 4 years of *** primary endpoint was defined by the presence of all-cause mortality and/or liver decompensation requiring liver *** patients who did not have a clinical note on December 31,2008 were considered as patients with an incomplete follow-up unless they reached a study endpoint(death or underwent liver transplantation) prior to that *** study was approved by the Institutional Review Boards of the Mayo ***:Of the 2441 patients with PSC observed in this period,104 patients(4.3%) had UC and underwent colectomy and were *** median age was 43.2 years,and 67% were *** leading indications for colectomy were severe colonic inflammation(49%),the presence of colonic dysplasia during routine surveillance(42%) and bowel perforation(3%).Twenty-six patients were lost to follow-up after a median duration of 3.9 *** remaining 78 patients included 52 patients(66.7%) who were followed for a median duration of 5.5 years and 26 patients(33.3%) who developed primary endpoints including death(n = 13) or underwent liver transplantation(n = 13) with a median follow up of 2.6 *** the secondary endpoint,the liver complications within 1 mo follow
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