Biotechnological Strategies of Riboflavin Biosynthesis in Microbes

作     者：Jia-Rong Zhang Ying-Ying Ge Pin-He Liu Ding-Tao Wu Hong-Yan Liu Hua-Bin Li Harold Corke Ren-You Gan Jia-Rong Zhang;Ying-Ying Ge;Pin-He Liu;Ding-Tao Wu;Hong-Yan Liu;Hua-Bin Li;Harold Corke;Ren-You Gan

作者机构：Research Center for Plants and Human HealthInstitute of Urban AgricultureChinese Academy of Agricultural SciencesChengdu 610213China Department of Food Science and TechnologySchool of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Coarse Cereal Processing(Ministry of Agriculture and Rural Affairs)Sichuan Engineering and Technology Research Center of Coarse Cereal IndustralizationChengdu UniversityChengdu 610106China Guangdong Provincial Key Laboratory of FoodNutrition and HealthDepartment of NutritionSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China Biotechnology and Food Engineering ProgramGuangdong Technion-Israel Institute of TechnologyShantou 515063China Faculty of Biotechnology and Food EngineeringTechnion-Israel Institute of TechnologyHaifa 32000Israel 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2022年第8卷第5期

页      面：115-127页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 07[理学] 

基　　金：supported by China Central Public-Interest Scientific Institution Basal Research Fund, Chinese Academy of Agricultural Sciences, China (Y2020XK05) the Shanghai Pujiang Talent Plan, Shanghai, China (18PJ1404600) 

主　　题：Vitamin B_(2) Bacillus subtilis Lactic acid bacteria Fungi Microbial fermentation 

摘      要：Riboflavin is an essential micronutrient for humans and must be obtained exogenously from foods or *** studies have suggested a major role of riboflavin in the prevention and treatment of various *** are mainly three strategies for riboflavin synthesis,including total chemical syn-thesis,chemical semi-synthesis,and microbial fermentation,the latter being currently the most promis-ing *** recent years,flavinogenic microbes have attracted increasing ***,including Eremothecium ashbyii and Ashbya gossypii,and bacteria,including Bacillus subtilis,Escherichia coli,and lac-tic acid bacteria,are ideal cell factories for riboflavin *** they are good candidates for enhancing the level of riboflavin in fermented foods or designing novel riboflavin bio-enriched foods with improved nutritional value and/or beneficial properties for human *** review briefly describes the role of riboflavin in human health and the historical process of its industrial production,and then highlights riboflavin biosynthesis in bacteria and fungi,and finally summarizes the strategies for ribofla-vin overproduction based on both the optimization of fermentation conditions and the development of riboflavin-overproducing strains via chemical mutagenesis and metabolic ***,this review provides an updated understanding of riboflavin biosynthesis and can promote the research and development of fermented food products rich in riboflavin.