Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression

作     者：Xiaoling Zeng Baohui Chen Luping Wang Yingxiao Sun Zhao Jin Xuanyong Liu Liping Ouyang Yun Liao 

作者机构：Department of PharmacyTongren HospitalShanghai Jiao Tong University School of MedicineShanghai200336China State Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing100049China Hongqiao International Institute of MedicineShanghai Jiao Tong University School of MedicineShanghai200336China School of Chemistry and Materials ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou310024China Cixi Center of Biomaterials Surface EngineeringShanghai Institute of CeramicsChinese Academy of SciencesNingbo315300China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第19卷第1期

页      面：653-665页

核心收录：

学科分类：081702[工学-化学工艺] 1002[医学-临床医学] 08[工学] 0817[工学-化学工程与技术] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(32071344,32000938,81974326,81403029) Natural Science Foundation of Shanghai(19ZR1449100) Science and Technology Commission of Shanghai Municipality(19JC1415500) S&T Innovation 2025 Major Special Program of Ningbo(2019B10063) 

主　　题：Hydrogel Diabetic skin wound healing Macrophages miR-29ab1 

摘      要：Wound healing is one of the major global health concerns in patients with *** of pro-inflammatory M1 macrophages is associated with delayed wound healing in ***-29ab1 plays a critical role in diabetes-related macrophage ***,inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound *** this study,the traditional Chinese medicine,puerarin,was introduced to construct an injectable and self-healing chitosan@puerarin(C@P)*** C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis,which were related to the inhibition of the miR-29 mediated inflammation *** to healthy subjects,miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model,accompanied by upregulated M1-polarization,and elevated levels of IL-1βand TNF-α.Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated *** present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory *** of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair.