Coagulation and Endothelial Dysfunction Associated with NAFLD:Current Status and Therapeutic Implications

作     者：Doris Ogresta Anna Mrzljak Maja Cigrovski Berkovic Ines Bilic-Curcic Sanja Stojsavljevic-Shapeski Lucija Virovic-Jukic Doris Ogresta;Anna Mrzljak;Maja Cigrovski Berkovic;Ines Bilic-Curcic;Sanja Stojsavljevic-Shapeski;Lucija Virovic-Jukic

作者机构：Department of Gastroenterology and HepatologySestre Milosrdnice University Hospital CenterZagrebCroatia Depart-ment of Gastroenterology and HepatologyUniversity Hospital Center ZagrebZagrebCroatia Department of MedicineUniversity of ZagrebSchool of MedicineZagrebCroatia Department for EndocrinologyDiabetes and PharmacologyUniversity Hospital DubravaZagrebCroatia Department of Kinesiological Anthropology and MethodologyFaculty of KinesiologyUniversity of Zagreb Department of PharmacologyFaculty of MedicineUniversity of JJ StrossmayerOsijekCroatia Department of DiabetesEndocrinology and Metabolism DisordersUniversity Hospital OsijekOsijekCroatia 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2022年第10卷第2期

页      面：339-355页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 08[工学] 

主　　题：Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Insulin resistance Coagulation Endothelial dysfunction Platelet dysfunction Thrombosis 

摘      要：Non-alcoholic fatty liver disease(NAFLD)is closely related to insulin resistance,type 2 diabetes mellitus,and *** is nowadays considered a multisystem disease with a strong association with cardiovascular disease and arterial hypertension,which interfere with changes in the coagulation *** disorders are common in patients with hepatic impairment and are dependent on the degree of liver *** with NAFLD may have preserved overall hemostatic profile,but many studies suggest a trend toward a procoagulant *** state in NAFLD patients may even induce progression of hepatic *** dysfunction is present in the systemic and portal vein circulation in NAFLD patients,and platelets are being recognized as modulators of liver diseases through various *** a literature review,we discuss possible disorders in the coagulation cascade and fibrinolysis,endothelial dysfunction,and platelet abnormalities in patients with *** the processes and mechanisms involved in the hemostatic abnormalities associated with NAFLD,directly related to liver disease or indirectly related through inflam-matory processes and metabolic disorders,several potential therapeutic targets have been identified and reviewed here.